Novel lansoprazole/glycyrrhizin spray dried complex: Physiochemical properties, photostability, and anti-ulcer activity on rats

被引:1
作者
Alsulays, Bader B. [1 ]
Anwer, Md Khalid [1 ]
Aodah, Alhussain H. [1 ]
Imam, Faisal [2 ]
机构
[1] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Pharmaceut, POB 173, AlKharj 11942, Saudi Arabia
[2] King Saud Univ, Coll Pharm, Dept Pharmacol & Toxicol, POB 2457, Riyadh 11451, Saudi Arabia
关键词
Lansoprazole; Glycyrrhizin; Spray dryer; Stability; Ulcer index; GLYCYRRHIZIC ACID; INCLUSION COMPLEXATION; GASTRIC DAMAGE; IN-VIVO; LANSOPRAZOLE; SOLUBILIZATION; STABILITY; SECRETION; RELEASE; ETHANOL;
D O I
10.1016/j.jddst.2023.105146
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Lansopraole (LNS) is one of the most frequently used anti-ulcer drug, but its poor aqueous solubility, low bioavailability, and instability limits its clinical application. In this study, glycyrrhizin (GLY), a natural complexing agent obtained from licorice was used to deliver lansoprazole (LNS) for the treatment of ulcer. LNS/GLY complexes with and without magnesium oxide (MgO) as an alkalizer were prepared using spray drying method in order to improve the release and stability of LNS, and examine its anti-ulcer effects on rats. Among three developed complexes (F1-F3), F3 complex (LNS/GLY (1:1.5 w/w, with MgO) was optimized with highest process yield (85.7 +/- 2.3%) and drug content (91 +/- 4.3%). The optimized spray-dried complex (F3) was further evaluated for DSC, FTIR, PXRD, SEM, photostability and in-vitro release studies. An enhanced drug release and improved photo-protection was confirmed by NMR studies. Further in-vivo anti-ulcer studies showed a significant alleviated macroscopic and microscopic stomach damage and reduction in hemorrhagic lesions and ulcer index.
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页数:11
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