Prognostic impact of serum testosterone in metastatic hormone-naive prostate cancer: a systematic review and meta-analysis

被引:2
作者
Puche-Sanz, Ignacio [1 ]
Chiu, Peter [2 ]
Morillo, Ana C. [3 ]
Gomez-Gomez, Enrique [3 ]
机构
[1] Granada Hosp Univ Virgen de las Nieves, Inst Invest Biosanitaria IBS, Dept Urol, Granada, Spain
[2] Chinese Univ Hong Kong, SH Ho Urol Ctr, Dept Surg, Hong Kong, Peoples R China
[3] UCO, Hosp Univ Reina Sofia, Dept Urol, IMIBIC, Cordoba, Spain
关键词
biomarker; hormone-sensitive prostate cancer; prognosis; prostate cancer; testosterone; ANDROGEN DEPRIVATION THERAPY; JAPANESE MEN; LEVEL; PROGRESSION; RISK; DUTASTERIDE; PREDICTORS; REDUCTION; SURVIVAL; BIOPSY;
D O I
10.1097/MOU.0000000000001132
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Purpose of reviewIn daily practice, there is an unmet medical need for biomarkers that facilitate therapeutic decision-making in the metastatic hormone sensitive prostate cancer (mHSPC) scenario. Although recent studies have highlighted the potential of testosterone as a prognostic and predictive marker in prostate cancer, the evidence is controversial. The objective of this review was to summarize and analyze the scientific evidence regarding the prognostic role of basal testosterone levels in patients with mHSPC.MethodsA systematic review was performed. Three authors selected the articles from Web of Science, PubMed, Scopus, and Cochrane Library electronic databases. Risk of bias was assessed by the Newcastle Ottawa Scale.Recent findingsMost of the selected articles suggest that low testosterone levels before starting hormonal blockade imply a worse prognosis for patients with mHSPC. However, the quality of the evidence is poor, the studies are heterogeneous, and it is not possible to meta-analyze most of the published results.SummaryTestosterone is an accessible and affordable biomarker. If it were correctly demonstrated that it harbors a prognostic and/or predictive role in the mHSPC setting, it could represent an advance in decision-making in these patients. Well designed prospective studies are needed to correctly answer this question.
引用
收藏
页码:472 / 481
页数:10
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