PET Radiotracers in Atherosclerosis: A Review

被引：4

作者：

Blanchard, Isabella ^{[1
]}

Vootukuru, Nishita ^{[1
]}

Bhattaru, Abhijit ^{[1
,2
]}

Patil, Shivaraj ^{[3
]}

Rojulpote, Chaitanya ^{[2
,4
,5
]}

机构：

[1] Rutgers New Jersey Med Sch, Dept Med, Newark, NJ USA

[2] Univ Penn, Dept Radiol, Philadelphia, PA USA

[3] Einstein Med Ctr, Dept Cardiol, Philadelphia, PA USA

[4] Wright Ctr Grad Med Educ, Dept Med, Scranton, PA 18505 USA

[5] Wright Ctr Grad Med Educ, 501 S Washington Ave Suite 1000, Scranton, PA 18505 USA

来源：

CURRENT PROBLEMS IN CARDIOLOGY | 2023年 / 48卷 / 11期

关键词：

POSITRON-EMISSION-TOMOGRAPHY; OPTICAL COHERENCE TOMOGRAPHY; CAROTID PLAQUE INFLAMMATION; 18F-SODIUM FLUORIDE UPTAKE; LOWER-EXTREMITY ARTERIES; F-18-SODIUM FLUORIDE; F-18-FDG PET; NAF-PET/CT; VASCULAR INFLAMMATION; CT-ANGIOGRAPHY;

D O I：

10.1016/j.cpcardiol.2023.101925

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Traditional atherosclerosis imaging modal-ities are limited to late stages of disease, prior to which patients are frequently asymptomatic. Positron emission tomography (PET) imaging allows for the visualization of metabolic processes underscoring disease progression via radioactive tracer, allowing earlier-stage disease to be identified. 2-deoxy-2-[fluo-rine-18]fluoro-D-glucose (18F-FDG) uptake largely reflects the metabolic activity of macrophages, but is unspecific and limited in its utility. By detecting areas of microcalcification, 18F-Sodium Fluoride (18F-NaF) uptake also provides insight into atherosclerosis pathogenesis. Gallium-68 DOTA-0-Tyr3-Octreotate (68Ga-DOTATATE) PET has also shown potential in identifying vulnerable atherosclerotic plaques with high somatostatin receptor expression. Finally, 11 -carbon (11C)-choline and 18F-fluoromethylcholine (FMCH) tracers may identify high-risk atheroscle-rotic plaques by detecting increased choline metabo-lism. Together, these radiotracers quantify disease burden, assess treatment efficacy, and stratify risk for adverse cardiac events. (Curr Probl Cardiol 2023;48:101925.)

引用

页数：30

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