Apelin-13, a regulator of autophagy, apoptosis and inflammation in multifaceted bone protection

被引：24

作者：

Gong, Ge ^{[1
]}

Wan, Wenhui ^{[1
]}

Liu, Xinhui ^{[2
]}

Yin, Jian ^{[2
]}

机构：

[1] Nanjing Univ, Jinling Hosp, Med Sch, Dept Geriatr, Nanjing 211002, Peoples R China

[2] Nanjing Med Univ, Affiliated Jiangning Hosp, Dept Orthoped, Nanjing 211100, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2023年 / 117卷

关键词：

Apelin-13; Bone protection; Osteoprotective effect; BMSCs; PANoptosis; MESENCHYMAL STEM-CELLS; ACUTE LUNG INJURY; TISSUE DISTRIBUTION; APELIN/APJ SYSTEM; OXIDATIVE STRESS; SKELETAL-MUSCLE; MESSENGER-RNA; WEAR DEBRIS; RECEPTOR; EXPRESSION;

D O I：

10.1016/j.intimp.2023.109991

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Apelin/APJ is widely distributed in various tissues in the body and participates in the regulation of physiological and pathological mechanisms such as autophagy, apoptosis, inflammation, and oxidative stress. Apelin-13 is an adipokine family member with multiple biological roles and has been shown to be involved in the development and progression of bone diseases. In the process of osteoporosis and fracture healing, Apelin-13 plays an osteoprotective role by regulating the autophagy and apoptosis of BMSCs, and promotes the osteogenic differ-entiation of BMSCs. In addition, Apelin-13 also attenuates the progression of arthritis by regulating the in-flammatory response of macrophages. In conclusion, Apelin-13 has an important connection with bone protection, which provides a new strategy for the clinical treatment of bone-related diseases.

引用

页数：8

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