Wnt Signaling Pathways: From Inflammation to Non-Melanoma Skin Cancers

被引：21

作者：

Di Bartolomeo, Luca ^{[1
]}

Vaccaro, Federico ^{[2
]}

Irrera, Natasha ^{[3
]}

Borgia, Francesco ^{[1
]}

Li Pomi, Federica ^{[1
]}

Squadrito, Francesco ^{[3
]}

Vaccaro, Mario ^{[1
]}

机构：

[1] Univ Messina, Dept Clin & Expt Med, Sect Dermatol, I-98125 Messina, Italy

[2] Univ Modena & Reggio Emilia, Dept Dermatol, I-41124 Modena, Italy

[3] Univ Messina, Sect Pharmacol, Dept Clin & Expt Med, I-98125 Messina, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 02期

关键词：

Wnt signaling; basal cell carcinoma; actinic keratosis; squamous cell carcinoma; SQUAMOUS-CELL CARCINOMA; BETA-CATENIN; E-CADHERIN; ACTINIC KERATOSIS; EXPRESSION; PROGRESSION; ACTIVATION; GROWTH; SNAIL; MICE;

D O I：

10.3390/ijms24021575

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Canonical and non-canonical Wnt signaling pathways are involved in cell differentiation and homeostasis, but also in tumorigenesis. In fact, an exaggerated activation of Wnt signaling may promote tumor growth and invasion. We summarize the most intriguing evidence about the role of Wnt signaling in cutaneous carcinogenesis, in particular in the pathogenesis of non-melanoma skin cancer (NMSC). Wnt signaling is involved in several ways in the development of skin tumors: it may modulate the inflammatory tumor microenvironment, synergize with Sonic Hedgehog pathway in the onset of basal cell carcinoma, and contribute to the progression from precancerous to malignant lesions and promote the epithelial-mesenchymal transition in squamous cell carcinoma. Targeting Wnt pathways may represent an additional efficient approach in the management of patients with NMSC.

引用

页数：14

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