Amide proton transfer imaging in stroke

被引:23
|
作者
Heo, Hye-Young [1 ,2 ]
Tee, Yee Kai [3 ]
Harston, George [4 ]
Leigh, Richard [5 ]
Chappell, Michael A. [6 ,7 ,8 ]
机构
[1] Johns Hopkins Univ, Dept Radiol, Div MR Res, Sch Med, 600 N Wolfe St,Pk 336, Baltimore, MD 21287 USA
[2] Kennedy Krieger Inst, FM Kirby Res Ctr Funct Brain Imaging, Baltimore, MD USA
[3] Univ Tunku Abdul Rahman, Lee Kong Chian Fac Engn & Sci, Kampar, Perak, Malaysia
[4] Oxford Univ Hosp NHS Fdn Trust, Acute Stroke Programme, Oxford, England
[5] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
[6] Univ Nottingham, Sch Med, Radiol Sci Mental Hlth & Clin Neurosci, Nottingham, England
[7] Univ Nottingham, Nottingham Biomed Res Ctr, Queens Med Ctr, Nottingham, England
[8] Univ Nottingham, Sir Peter Mansfield Imaging Ctr, Sch Med, Nottingham, England
基金
美国国家卫生研究院;
关键词
APT; CEST; ischemic penumbra; pH imaging; stroke; CEREBRAL BLOOD-FLOW; ISCHEMIC PENUMBRA; MAGNETIZATION-TRANSFER; HYPERACUTE STROKE; CEST-MRI; QUANTITATIVE DESCRIPTION; WEIGHTED MRI; HUMAN BRAIN; PERFUSION; DIFFUSION;
D O I
10.1002/nbm.4734
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Amide proton transfer (APT) imaging, a variant of chemical exchange saturation transfer MRI, has shown promise in detecting ischemic tissue acidosis following impaired aerobic metabolism in animal models and in human stroke patients due to the sensitivity of the amide proton exchange rate to changes in pH within the physiological range. Recent studies have demonstrated the possibility of using APT-MRI to detect acidosis of the ischemic penumbra, enabling the assessment of stroke severity and risk of progression, monitoring of treatment progress, and prognostication of clinical outcome. This paper reviews current APT imaging methods actively used in ischemic stroke research and explores the clinical aspects of ischemic stroke and future applications for these methods.
引用
收藏
页数:14
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