Gamma irradiation-induced degradation and mineralization of methocarbamol in aqueous solution

被引:2
|
作者
Zaouak, Amira [1 ]
Chouchane, Habib [2 ]
Jelassi, Haikel [1 ]
机构
[1] Natl Ctr Nucl Sci & Technol, Res Lab Energy & Matter Nucl Sci Dev LR16CNSTN02, Sidi Thabet Technopk 2020, Tunis, Tunisia
[2] Univ Manouba, ISBST, Biotechpole Sidi Thabet, LR11 ES31 BVBGR, Ariana 2020, Tunisia
关键词
Gamma irradiation; methocarbamol; kinetic study; by-products; GC-MS; ELECTROCHEMICAL OXIDATION; HYDROXYL RADICALS; WASTE-WATER; POLLUTANTS; MECHANISM; RADIATION; ACID; ELECTROCOAGULATION; PHARMACEUTICALS; HERBICIDE;
D O I
10.1080/09593330.2022.2046646
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Gamma irradiation degradation of the extensively used muscle relaxant in the world methocarbamol (MET) was studied. MET aqueous solutions were irradiated by gamma rays emitted by a Cobalt 60 source at doses of 1-4 kGy. Our findings demonstrated that gamma irradiation degraded more than 98.5% of MET. Absorption spectra analysis revealed that when increased irradiation dose, the absorption bands declined with complete disappearance at 4 kGy dose. Additionally, the most radiolytic degradation rate was recorded at neutral pH, marked by Total Organic Carbon (TOC) removal rate of 98% reflecting the total mineralization of MET at 4 kGy. In-depth spectrophotometric analyses advocated a pseudo-first-order type of MET degradation kinetics. The obtained apparent rate constant value was k(app, MET) = (0.02167 +/- 0.0006) min(-1). Gas chromatography-mass spectrometry (GC-MS) allowed the detection of 3-(o-methoxyphenoxy)-1,2 propanediol,2-methoxyphenol, 1,2,3 propanetriol, 1,2-dihydroxybenzene and 1,2,4 benzentriol identified as by-products generated during radiolytic degradation. Finally, an outline of the degradation mechanism was suggested according to the obtained by-products.
引用
收藏
页码:2856 / 2863
页数:8
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