Secondary metabolites from a deep-sea derived fungal strain of Phomopsis lithocarpus FS508

被引：5
作者：
Hu, Jinhua [1 ,2 ]
Wang, Nuoyi [1 ,2 ]
Liu, Hongxin [2 ]
Li, Saini [2 ]
Liu, Zhaoming [2 ]
Zhang, Weimin [2 ]
Gao, Xiaoxia [1 ]
机构：
[1] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou, Peoples R China
[2] Guangdong Acad Sci, Inst Microbiol, State Key Lab Appl Microbiol Southern China, Guangdong Prov Key Lab Microbial Culture Collect, Guangzhou, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 14期
关键词：
Marine fungus; Phomopsis lithocarpus; cytotoxicity; isoindolinone lactam; A-C; ACYCLIC TRITERPENOIDS; DERIVATIVES;
D O I：
10.1080/14786419.2022.2044810
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
One new isoindolinone lactam lithocarlactam A (1) and one new triterpene lithocarin D (2), along with nine known natural products (3-11) were isolated from the broth extract of marine fungus Phomopsis lithocarpus FS508, which was isolated from a deep-sea sediment sample. Their structures were elucidated by interpretation of spectroscopic analysis and comparison with previously published literatures for the known compounds. Moreover, compounds 1 and 2 were evaluated for cytotoxic activity against SF-268, MCF-7, HepG-2, and A549 cell lines. However, both of them showed no activity against the tumor cell lines.
引用
收藏
页码：2351 / 2358
页数：8
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