Epigenetics and the neurodegenerative process

被引：1

作者：

Slowikowski, Bartosz ^{[1
]}

Owecki, Wojciech ^{[2
]}

Jeske, Jan ^{[2
]}

Jezierski, Michal ^{[2
]}

Dragula, Michal ^{[2
]}

Goutor, Ulyana ^{[2
]}

Jagodzinski, Pawel P. ^{[1
]}

Kozubski, Wojciech ^{[3
]}

Dorszewska, Jolanta ^{[2
]}

机构：

[1] Poznan Univ Med Sci, Dept Biochem & Mol Biol, PL-61701 Poznan, Poland

[2] Poznan Univ Med Sci, Dept Neurol, Lab Neurobiol, PL-61701 Poznan, Poland

[3] Poznan Univ Med Sci, Chair & Dept Neurol, PL-61701 Poznan, Poland

来源：

EPIGENOMICS | 2024年 / 16卷 / 07期

关键词：

DNA; epigenetics modifications; neurodegeneration; neuroinflammation; RNA; PARKINSONS-DISEASE; DNA METHYLATION; HISTONE ACETYLATION; ALZHEIMERS-DISEASE; ALPHA-SYNUCLEIN; PROMOTER METHYLATION; VASCULAR DEMENTIA; GENE-EXPRESSION; CELL-DEATH; MECHANISMS;

D O I：

10.2217/epi-2023-0416

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Neurological diseases are multifactorial, genetic and environmental. Environmental factors such as diet, physical activity and emotional state are epigenetic factors. Environmental markers are responsible for epigenetic modifications. The effect of epigenetic changes is increased inflammation of the nervous system and neuronal damage. In recent years, it has been shown that epigenetic changes may cause an increased risk of neurological disorders but, currently, the relationship between epigenetic modifications and neurodegeneration remains unclear. This review summarizes current knowledge about neurological disorders caused by epigenetic changes in diseases such as Alzheimer's disease, Parkinson's disease, stroke and epilepsy. Advances in epigenetic techniques may be key to understanding the epigenetics of central changes in neurological diseases. Created with with BioRender.com

引用

页码：473 / 491

页数：20

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