Recent advances in the use of SPME for drug analysis in clinical, toxicological, and forensic medicine studies

被引：16

作者：

Leszczynska, Dagmara ^{[1
]}

Hallmann, Anna ^{[1
]}

Treder, Natalia ^{[2
]}

Baczek, Tomasz ^{[2
]}

Roszkowska, Anna ^{[2
]}

机构：

[1] Med Univ Gdansk, Dept Pharmaceut Biochem, PL-80211 Gdansk, Poland

[2] Med Univ Gdansk, Dept Pharmaceut Chem, PL-80416 Gdansk, Poland

来源：

TALANTA | 2024年 / 270卷

关键词：

Solid-phase microextraction; Therapeutic drug monitoring; Biological matrices; SOLID-PHASE MICROEXTRACTION; IONIZATION MASS-SPECTROMETRY; THIN-FILM MICROEXTRACTION; LIQUID-CHROMATOGRAPHY; HUMAN PLASMA; IN-VIVO; WATER SAMPLES; FIBER; NANOCOMPOSITE; QUANTITATION;

D O I：

10.1016/j.talanta.2023.125613

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Solid-phase microextraction (SPME) has gained attention as a simple, fast, and non-exhaustive extraction technique, as its unique features enable its use for the extraction of many classes of drugs from biological matrices. This sample-preparation approach consolidates sampling and sample preparation into a single step, in addition to providing analyte preconcentration and sample clean-up. These features have helped SPME become an integral part of several analytical protocols for monitoring drug concentrations in human matrices in clinical, toxicological, and forensic medicine studies. Over the years, researchers have continued to develop the SPME technique, resulting in the introduction of novel sorbents and geometries, which have resulted in improved extraction efficiencies. This review summarizes developments and applications of SPME published between 2016 and 2022, specifically in relation to the analysis of central nervous system drugs, drugs used to treat cardiovascular disorders and bacterial infections, and drugs used in immunosuppressive and anticancer therapies.

引用

页数：29