Nanoformulated meloxicam and rifampin: inhibiting quorum sensing and biofilm formation in Pseudomonas aeruginosa

被引：3

作者：

Khorramdel, Malihe ^{[1
]}

Ghadikolaii, Fatemeh Peyravii ^{[2
]}

Hashemy, Seyed, I ^{[3
,4
]}

Javid, Hossein ^{[3
,4
,5
]}

Tabrizi, Masoud H. ^{[6
]}

机构：

[1] Islamic Azad Univ, Dept Microbiol, Ayatollah Amoli Branch, Amol, Iran

[2] Islamic Azad Univ, Dept Biol, Qaemshahr Branch, Qaemshahr, Iran

[3] Mashhad Univ Med Sci, Surg Oncol Res Ctr, Mashhad, Iran

[4] Mashhad Univ Med Sci, Fac Med, Dept Clin Biochem, Mashhad, Iran

[5] Varastegan Inst Med Sci, Dept Med Lab Sci, Mashhad, Iran

[6] Islamic Azad Univ, Dept Biol, Mashhad Branch, Mashhad, Iran

来源：

NANOMEDICINE | 2024年 / 19卷 / 07期

关键词：

biofilm formation; meloxicam; nanostructured lipid carrier; NLC; Pseudomonas aeruginosa; quorum sensing; rifampin; SLN; solid lipid nanoparticle; SOLID LIPID NANOPARTICLES; CARRIERS; QUANTIFICATION; STRATEGIES; SYSTEMS; SLN;

D O I：

10.2217/nnm-2023-0268

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Background: We aimed to investigate the simultaneous effects of meloxicam and rifampin nanoformulations with solid lipid nanoparticle (SLN) and nanostructured lipid carrier (NLC) substrates on inhibiting the quorum-sensing system of Pseudomonas aeruginosa and preventing biofilm formation by this bacterium. Methods: Antimicrobial activity of rifampin and meloxicam encapsulated with SLNs and NLCs against P. aeruginosa PAO1 was assessed by disk diffusion, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Results: The SLN formulation was associated with lower doses for the MIC and minimum bactericidal concentration in comparison to NLC. Moreover, our results demonstrated that both nanoformulations were able to produce 100% inhibition of the biofilm formation of P. aeruginosa PAO1. Conclusion: All these findings suggest that meloxicam and rifampin encapsulated with SLNs could be the most effective formulation against P. aeruginosa.

引用

页码：615 / 632

页数：18

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