Bacterial outer membrane vesicles in cancer: Biogenesis, pathogenesis, and clinical application

被引：23

作者：

Li, Deming ^{[1
]}

Zhu, Lisi ^{[2
]}

Wang, Yuxiao ^{[1
]}

Zhou, Xiangyu ^{[2
]}

Li, Yan ^{[2
]}

机构：

[1] China Med Univ, Affiliated Hosp 4, Anesthesia Dept, Shenyang 110032, Liaoning, Peoples R China

[2] China Med Univ, Affiliated Hosp 4, Dept Gen Surg, Shenyang 110032, Liaoning, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 165卷

关键词：

Outer membrane vesicles (OMVs); Tumor microenvironment (TME); Cancer; Biomarkers; Tumor therapy; Vaccination; GRAM-NEGATIVE BACTERIA; NECROSIS-FACTOR-ALPHA; TOL-PAL COMPLEX; ESCHERICHIA-COLI; PSEUDOMONAS-AERUGINOSA; PORPHYROMONAS-GINGIVALIS; EXTRACELLULAR VESICLES; ENVELOPE STRESS; TUMOR; RECEPTOR;

D O I：

10.1016/j.biopha.2023.115120

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Outer membrane vesicles (OMVs) are spherical, nano-sized particles of bilayer lipid structure secreted by Gramnegative bacteria. They contain a series of cargos from bacteria and are important messengers for communication between bacteria and their environment. OMVs play multiple roles in bacterial survival and adaptation and can affect host physiological functions and disease development by acting on host cell membranes and altering host cell signaling pathways. This paper summarizes the mechanisms of OMV genesis and the multiple roles of OMVs in the tumor microenvironment. Also, this paper discusses the prospects of OMVs for a wide range of applications in drug delivery, tumor diagnosis, and therapy.

引用

页数：11

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