Roles of interferon induced protein with tetratricopeptide repeats (IFIT) family in autoimmune disease

被引：8
|
作者：
Wu, Yuan-Yuan [1 ]
Xing, Jun [5 ]
Li, Xiao-Feng [2 ,3 ,4 ]
Yang, Ying-Li [2 ,3 ,4 ]
Shao, Hua [1 ]
Li, Jun [2 ,3 ,4 ]
机构：
[1] Southeast Univ, Zhong da Hosp, Dept Pharm, 87 Ding Jia Qiao, Nanjing 210009, Peoples R China
[2] Minist Educ, Anhui Inst Innovat Drugs, Key Lab Antiinflammatory & Immune Med, Hefei, Anhui, Peoples R China
[3] Inflammat & Immune Mediated Dis Lab Anhui Prov, Hefei, Anhui, Peoples R China
[4] Anhui Med Univ, Sch Pharm, Hefei, Anhui, Peoples R China
[5] China Med Univ, Shenyang 110122, Peoples R China
来源：
AUTOIMMUNITY REVIEWS | 2023年 / 22卷 / 11期
基金：
中国国家自然科学基金;
关键词：
IFIT family; Autoimmune disease; IFN-I signaling pathway; Diagnostics; Treatment; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CONNECTIVE-TISSUE; GENE; EXPRESSION; BIOMARKERS;
D O I：
10.1016/j.autrev.2023.103453
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Interferon-induced tetrapeptide repeat (IFIT) family proteins are an important component of the antiviral immune response. There are four known members of the human IFIT family, namely IFIT1, IFIT2, IFIT3 and IFIT5. More and more evidence shows that IFIT family members are involved in a variety of pathophysiological processes in vivo, regulate the homeostasis and differentiation of a variety of cells including immune cells, and are closely related to a variety of autoimmune diseases, which is expected to become a new therapeutic target. This review reviews the biological roles of different IFIT proteins in various autoimmune diseases, and highlights the potential use of these molecules as biomarkers and prognostic factors in autoimmune diseases, with a view to providing ideas for exploring the diagnosis and treatment of autoimmune diseases.
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页数：8
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