Recent research advances on oral colon-specific delivery system of nature bioactive components: A review

被引：12

作者：

Zhao, Shuang ^{[1
]}

Zhao, Yan ^{[1
]}

Yang, Xingbin ^{[2
]}

Zhao, Tong ^{[2
]}

机构：

[1] Shaanxi Normal Univ, Coll Life Sci, Key Lab, Minist Educ Med Resource & Nat Pharmaceut Chem, Xian 710119, Peoples R China

[2] Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Shaanxi Engn Lab Food Green Proc & Safety Control, Xian 710119, Peoples R China

来源：

FOOD RESEARCH INTERNATIONAL | 2023年 / 173卷

基金：

中国国家自然科学基金;

关键词：

Bioactive components; Oral colon-specific; Delivery systems; Influence factors; Types of carriers; Preparation strategies; INFLAMMATORY-BOWEL-DISEASE; NF-KAPPA-B; DRUG-DELIVERY; TARGETED DELIVERY; SODIUM ALGINATE; CHITOSAN; COLITIS; DESIGN; POLYSACCHARIDES; NANOPARTICLES;

D O I：

10.1016/j.foodres.2023.113403

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Oral colon-specific delivery system (OCDS) is a targeted approach that aims to directly deliver bioactive com-pounds directly to the colon following oral administration, thereby enhancing the colonic release of bioactive substances and minimizing adverse reactions. The effectiveness of bioactive substances in the colon hinges on the degree of release, which are affected by various factors including pH, mucosal barrier, delivery time and so on. Therefore, this review provides a comprehensive overview of the key factors affecting oral colon-specific release of bioactive components firstly. Considering the oral safety, this review then mainly focuses on the types of carriers with edible OCDS and preparation strategies for OCDS. Finally, several preparation strategies for loading typical natural bioactive ingredients into oral safe OCDS are reviewed, along with future development prospects.

引用

页数：13

共 127 条

[41] Kalopanaxsaponin A ameliorates experimental colitis in mice by inhibiting IRAK-1 activation in the NF-κB and MAPK pathways [J].

Joh, Eun-Ha ;

Kim, Dong-Hyun .

BRITISH JOURNAL OF PHARMACOLOGY, 2011, 162 (08) :1731-1742

[42] Lancemaside A ameliorates colitis by inhibiting NF-κB activation in TNBS-induced colitis mice [J].

Joh, Eun-Ha ;

Lee, In-Ah ;

Han, Sang-Jun ;

Chae, SunJu ;

Kim, Dong-Hyun .

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 2010, 25 (05) :545-551

[43] Colon Targeted Drug Delivery: Different Approaches [J].

Jose, S. ;

Dhanya, K. ;

Cinu, T. A. ;

Litty, J. ;

Chacko, A. J. .

JOURNAL OF YOUNG PHARMACISTS, 2009, 1 (01) :13-19

[44] Characterization and storage stability of chlorophylls microencapsulated in different combination of gum Arabic and maltodextrin [J].

Kang, Yu-Ra ;

Lee, Yun-Kyung ;

Kim, Young Jun ;

Chang, Yoon Hyuk .

FOOD CHEMISTRY, 2019, 272 :337-346

[45] The four epidemiological stages in the global evolution of inflammatory bowel disease [J].

Kaplan, Gilaad G. ;

Windsor, Joseph W. .

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2021, 18 (01) :56-66

[46] In vivo efficacy of microbiota-sensitive coatings for colon targeting: A promising tool for IBD therapy [J].

Karrout, Y. ;

Dubuquoy, L. ;

Piveteau, C. ;

Siepmann, F. ;

Moussa, E. ;

Wils, D. ;

Beghyn, T. ;

Neut, C. ;

Flament, M. -P. ;

Guerin-Deremaux, L. ;

Dubreuil, L. ;

Deprez, B. ;

Desreumaux, P. ;

Siepmann, J. .

JOURNAL OF CONTROLLED RELEASE, 2015, 197 :121-130

[47] Characterization of ethylcellulose: starch-based film coatings for colon targeting [J].

Karrout, Youness ;

Neut, Christel ;

Wils, Daniel ;

Siepmann, Florence ;

Deremaux, Laetitia ;

Desreumaux, Pierre ;

Siepmann, Juergen .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2009, 35 (10) :1190-1200

[48] Monocyclic Phenolic Acids; Hydroxy- and Polyhydroxybenzoic Acids: Occurrence and Recent Bioactivity Studies [J].

Khadem, Shahriar ;

Marles, Robin J. .

MOLECULES, 2010, 15 (11) :7985-8005

[49] Ternary nanocomposite carriers based on organic clay-lipid vesicles as an effective colon-targeted drug delivery system: preparation and in vitro/in vivo characterization [J].

Kim, Hyeon Young ;

Cheon, Jae Hee ;

Lee, Sang Hoon ;

Min, Jeong Youn ;

Back, Seung-Yun ;

Song, Jae Geun ;

Kim, Da Hye ;

Lim, Soo-Jeong ;

Han, Hyo-Kyung .

JOURNAL OF NANOBIOTECHNOLOGY, 2020, 18 (01)

[50] Changing patterns in the epidemiology and outcomes of inflammatory bowel disease in the United Kingdom: 2000-2018 [J].

King, Dominic ;

Reulen, Raoul C. ;

Thomas, Tom ;

Chandan, Joht Singh ;

Thayakaran, Rasiah ;

Subramanian, Anuradhaa ;

Gokhale, Krishna ;

Bhala, Neeraj ;

Nirantharakumar, Krishnarajah ;

Adderley, Nicola J. ;

Trudgill, Nigel .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2020, 51 (10) :922-934

← 1 2 3 4 5 6 7 8 9 10 →