Recent research advances on oral colon-specific delivery system of nature bioactive components: A review

被引：12

作者：

Zhao, Shuang ^{[1
]}

Zhao, Yan ^{[1
]}

Yang, Xingbin ^{[2
]}

Zhao, Tong ^{[2
]}

机构：

[1] Shaanxi Normal Univ, Coll Life Sci, Key Lab, Minist Educ Med Resource & Nat Pharmaceut Chem, Xian 710119, Peoples R China

[2] Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Shaanxi Engn Lab Food Green Proc & Safety Control, Xian 710119, Peoples R China

来源：

FOOD RESEARCH INTERNATIONAL | 2023年 / 173卷

基金：

中国国家自然科学基金;

关键词：

Bioactive components; Oral colon-specific; Delivery systems; Influence factors; Types of carriers; Preparation strategies; INFLAMMATORY-BOWEL-DISEASE; NF-KAPPA-B; DRUG-DELIVERY; TARGETED DELIVERY; SODIUM ALGINATE; CHITOSAN; COLITIS; DESIGN; POLYSACCHARIDES; NANOPARTICLES;

D O I：

10.1016/j.foodres.2023.113403

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Oral colon-specific delivery system (OCDS) is a targeted approach that aims to directly deliver bioactive com-pounds directly to the colon following oral administration, thereby enhancing the colonic release of bioactive substances and minimizing adverse reactions. The effectiveness of bioactive substances in the colon hinges on the degree of release, which are affected by various factors including pH, mucosal barrier, delivery time and so on. Therefore, this review provides a comprehensive overview of the key factors affecting oral colon-specific release of bioactive components firstly. Considering the oral safety, this review then mainly focuses on the types of carriers with edible OCDS and preparation strategies for OCDS. Finally, several preparation strategies for loading typical natural bioactive ingredients into oral safe OCDS are reviewed, along with future development prospects.

引用

页数：13

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