Total syntheses of pongaflavone and its natural analogues

被引：3
|
作者：
Yu, Pei [1 ]
Long, Bin [1 ]
Feng, Chuan-Ling [1 ]
Yang, Ting-Ting [1 ]
Jiang, Xi-Lan [2 ]
He, Yu-Jiao [1 ]
Dong, Hong-Bo [1 ]
机构：
[1] Chengdu Univ, Sch Pharm, Antibiot Res & Reevaluat Key Lab Sichuan Prov, Chengdu 610106, Peoples R China
[2] Chengdu Inst Food Inspect, Inst Hlth Food Inspect & Evaluat, Chengdu 611130, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2023年 / 25卷 / 11期
基金：
中国国家自然科学基金;
关键词：
Pongaflavone; pongachromene; 7; 8-(2; 2"-dimethylpyrano)-5; 3'; 4'-trihydroxy-3-methoxyflavone; total synthesis; anti-tumor activity; natural product; PONGACHROMENE; AGENTS;
D O I：
10.1080/10286020.2023.2193697
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The efficient total synthesis of anti-tumor natural product pongaflavone (1) was described starting from commercially available 2,4-dihydroxyacetophenone (9) via seven steps and in 16% overall yield. Its two natural analogues pongachromene (2) and 7,8-(2",2"-dimethylpyrano)-5,3',4'-trihydroxy-3-methoxyflavone (3) were also synthesized following the similar procedure with the yields of 11% and 18%, respectively. Their preliminary anti-tumor activities were evaluated by the inhibition effect on A549 cells. The result showed that this kind of natural products exhibited different levels of anti-tumor activity. Among them, pongachromene (2) displayed the best anti-tumor activity.
引用
收藏
页码：1085 / 1096
页数：12
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