Synthesis of new sulfapyrimidine and pyrazolo[1,5-a]pyrimidine derivatives

被引：3

作者：

Ahmed, Ebtsam A. A. ^{[1
,2
,3
]}

Elgemeie, Galal H. H. ^{[1
]}

Azzam, Rasha A. A. ^{[1
]}

机构：

[1] Helwan Univ, Fac Sci, Dept Chem, Cairo, Egypt

[2] King Faisal Univ, Coll Sci, Dept Chem, Al Hufuf, Saudi Arabia

[3] King Faisal Univ, Coll Sci, Fac Sci, Dept Chem, Al Hufuf 31982, Al Ahsa, Saudi Arabia

来源：

SYNTHETIC COMMUNICATIONS | 2023年 / 53卷 / 05期

关键词：

Pyrazoles; pyrazolopyrimidines; pyrimidines; sulfaguanidines; sulfapyrimidines; BIOLOGICAL EVALUATION; ANALOGS; INHIBITORS; DOCKING; DESIGN; ROUTE;

D O I：

10.1080/00397911.2023.2175694

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of new pyrimidine derivatives were synthesized, including sulfapyrimidines and pyrazolo[1,5-a]pyrimidines. In basic medium, pyrimidine compounds were produced by reacting sulfa guanidine with either 2-cyano-3-(dimethylamino)-N-acrylamides or N-(4-chlorophenyl)-2-cyano-3-(4-aryl)-acrylamides. The reaction of 5-amino-1H-pyrazole-4-carboxamides with either 2-cyano-3-(dimethylamino)-N-acrylamides or N-(4-chlorophenyl)-2-cyano-3-(4-aryl)acrylamides resulted in the synthesis of pyrazolo[1,5-a]pyrimidine compounds.

引用

页码：386 / 401

页数：16

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