Synthesis of new sulfapyrimidine and pyrazolo[1,5-a]pyrimidine derivatives

被引：3
|
作者：
Ahmed, Ebtsam A. A. [1 ,2 ,3 ]
Elgemeie, Galal H. H. [1 ]
Azzam, Rasha A. A. [1 ]
机构：
[1] Helwan Univ, Fac Sci, Dept Chem, Cairo, Egypt
[2] King Faisal Univ, Coll Sci, Dept Chem, Al Hufuf, Saudi Arabia
[3] King Faisal Univ, Coll Sci, Fac Sci, Dept Chem, Al Hufuf 31982, Al Ahsa, Saudi Arabia
来源：
SYNTHETIC COMMUNICATIONS | 2023年 / 53卷 / 05期
关键词：
Pyrazoles; pyrazolopyrimidines; pyrimidines; sulfaguanidines; sulfapyrimidines; BIOLOGICAL EVALUATION; ANALOGS; INHIBITORS; DOCKING; DESIGN; ROUTE;
D O I：
10.1080/00397911.2023.2175694
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of new pyrimidine derivatives were synthesized, including sulfapyrimidines and pyrazolo[1,5-a]pyrimidines. In basic medium, pyrimidine compounds were produced by reacting sulfa guanidine with either 2-cyano-3-(dimethylamino)-N-acrylamides or N-(4-chlorophenyl)-2-cyano-3-(4-aryl)-acrylamides. The reaction of 5-amino-1H-pyrazole-4-carboxamides with either 2-cyano-3-(dimethylamino)-N-acrylamides or N-(4-chlorophenyl)-2-cyano-3-(4-aryl)acrylamides resulted in the synthesis of pyrazolo[1,5-a]pyrimidine compounds.
引用
收藏
页码：386 / 401
页数：16
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