A Retrospective Study of the Safety and Immunogenicity of MVC-COV1901 Vaccine for People Living with HIV

被引：4

作者：

Cheng, Shu-Hsing ^{[1
,2
]}

Lien, Chia En ^{[3
,4
]}

Hsieh, Szu-Min ^{[5
,6
]}

Cheng, Chien-Yu ^{[1
,4
]}

Liu, Wang-Da ^{[5
,7
]}

Lo, Ching-Lung ^{[8
,9
]}

Ko, Wen-Chien ^{[8
,9
]}

Chen, Yen-Hsu ^{[10
,11
,12
]}

Huang, Ching-Tai ^{[13
,14
]}

Chang, Hsiao-Ting ^{[15
,16
]}

Hwang, Shinn-Jang ^{[15
,16
]}

Wang, Ning-Chi ^{[17
]}

Liu, Ming-Che ^{[18
,19
]}

Lee, Yu-Lin ^{[20
,21
]}

Tai, I-Chen ^{[3
]}

Estrada, Josue Antonio Garcia ^{[3
]}

Lin, Tzou-Yien ^{[14
,22
]}

Lee, Wen-Sen ^{[23
,24
]}

机构：

[1] Taoyuan Gen Hosp, Dept Infect Dis, Minist Hlth & Welf, Taoyuan 330, Taiwan

[2] Taipei Med Univ, Sch Publ Hlth, Taipei 110, Taiwan

[3] Medigen Vaccine Biol, Taipei 114, Taiwan

[4] Natl Yang Ming Chiao Tung Univ, Inst Publ Hlth, Coll Med, Taipei 112, Taiwan

[5] Natl Taiwan Univ Hosp, Dept Internal Med, Div Infect Dis, Taipei 100, Taiwan

[6] Natl Taiwan Univ, Coll Med, Taipei 106, Taiwan

[7] Natl Taiwan Univ, Dept Med, Canc Ctr, Taipei 100, Taiwan

[8] Natl Cheng Kung Univ Hosp, Dept Internal Med, Tainan 704, Taiwan

[9] Natl Cheng Kung Univ, Coll Med, Dept Med, Tainan 701, Taiwan

[10] Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung 807, Taiwan

[11] Kaohsiung Med Univ, Grad Inst Med, Sepsis Res Ctr, Sch Med, Kaohsiung 807, Taiwan

[12] Kaohsiung Med Univ, Ctr Trop Med & Infect Dis, Kaohsiung 807, Taiwan

[13] Chang Gung Mem Hosp, Dept Infect Dis, Taoyuan 333, Taiwan

[14] Chang Gung Univ, Coll Med, Taoyuan 333, Taiwan

[15] Taipei Vet Gen Hosp, Dept Family Med, Taipei 112, Taiwan

[16] Natl Yang Ming Chiao Tung Univ, Sch Med, Taipei 112, Taiwan

[17] Triserv Gen Hosp, Taipei 114, Taiwan

[18] Taipei Med Univ Hosp, Clin Res Ctr, Taipei 110, Taiwan

[19] Taipei Med Univ, Coll Oral Med, Sch Dent Technol, Taipei 110, Taiwan

[20] Changhua Christian Hosp, Dept Internal Med, Changhua 500, Taiwan

[21] Natl Chung Hsing Univ, Program Med Biotechnol, Taichung 402, Taiwan

[22] Chang Gung Mem Hosp, Dept Paediat, Taoyuan 333, Taiwan

[23] Taipei Med Univ, Wan Fang Hosp, Dept Internal Med, Div Infect Dis, Taipei 116, Taiwan

[24] Taipei Med Univ, Coll Med, Sch Med, Dept Internal Med, Taipei 110, Taiwan

来源：

VACCINES | 2023年 / 11卷 / 01期

关键词：

COVID-19; vaccine; CpG; 1018; S-2P protein; HIV; CD4; CD8; ratio; immunogenicity; HUMAN-IMMUNODEFICIENCY-VIRUS; HEPATITIS-B VACCINATION; T-CELL DIFFERENTIATION; ANTIBODY-RESPONSE; COVID-19; VACCINE; MESSENGER-RNA; SARS-COV-2; INFECTION; NUMBER; ADULTS;

D O I：

10.3390/vaccines11010018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: This study aimed to assess the safety and immunogenicity of MVC-COV1901, a recombinant COVID-19 protein vaccine, containing S-2P protein adjuvanted with CpG 1018 and aluminum hydroxide, for people living with HIV (PWH). Methods: A total of 57 PWH of >= 20 years of age who are on stable antiretroviral therapy were compared with 882 HIV-negative participants. Participants received two doses of MVC-COV1901 28 days apart. Results: No vaccine-related serious adverse events (SAEs) were recorded. Seroconversion rates (SCRs) of 100% and 99.8% were achieved in PWH and comparators, respectively, 28 days after the second dose. After adjusting for sex, age, BMI category, and comorbidity, the adjusted GMT ratio of comparator/PWH was 3.2 (95% CI 2.5-4). A higher CD4/CD8 ratio was associated with a higher GMT (R = 0.27, p = 0.039). MVC-COV1901 has shown robust safety but elicited weaker immune responses in PWH. Conclusions: Further investigations may be needed to determine whether PWH require distinct immunization strategies with improved immunogenicity. The main study is registered at ClinicalTrials.gov (NCT04695652).

引用

页数：14

共 58 条

[41]

Peebody R., 2021, HAVE COVID 19 VACCIN

[42] Sharing CD4+T Cell Loss: When COVID-19 and HIV Collide on Immune System [J].

Peng, Xiaorong ;

Ouyang, Jing ;

Isnard, Stephane ;

Lin, John ;

Fombuena, Brandon ;

Zhu, Biao ;

Routy, Jean-Pierre .

FRONTIERS IN IMMUNOLOGY, 2020, 11

[43] Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine [J].

Polack, Fernando P. ;

Thomas, Stephen J. ;

Kitchin, Nicholas ;

Absalon, Judith ;

Gurtman, Alejandra ;

Lockhart, Stephen ;

Perez, John L. ;

Perez Marc, Gonzalo ;

Moreira, Edson D. ;

Zerbini, Cristiano ;

Bailey, Ruth ;

Swanson, Kena A. ;

Roychoudhury, Satrajit ;

Koury, Kenneth ;

Li, Ping ;

Kalina, Warren V. ;

Cooper, David ;

Frenck, Robert W., Jr. ;

Hammitt, Laura L. ;

Tureci, Ozlem ;

Nell, Haylene ;

Schaefer, Axel ;

Unal, Serhat ;

Tresnan, Dina B. ;

Mather, Susan ;

Dormitzer, Philip R. ;

Sahin, Ugur ;

Jansen, Kathrin U. ;

Gruber, William C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (27) :2603-2615

[44] Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19 [J].

Sadoff, Jerald ;

Gray, Glenda ;

Vandebosch, An ;

Cardenas, Vicky ;

Shukarev, Georgi ;

Grinsztejn, Beatriz ;

Goepfert, Paul A. ;

Truyers, Carla ;

Fennema, Hein ;

Spiessens, Bart ;

Offergeld, Kim ;

Scheper, Gert ;

Taylor, Kimberly L. ;

Robb, Merlin L. ;

Treanor, John ;

Barouch, Dan H. ;

Stoddard, Jeffrey ;

Ryser, Martin F. ;

Marovich, Mary A. ;

Neuzil, Kathleen M. ;

Corey, Lawrence ;

Cauwenberghs, Nancy ;

Tanner, Tamzin ;

Hardt, Karin ;

Ruiz-Guinazu, Javier ;

Le Gars, Mathieu ;

Schuitemaker, Hanneke ;

Van Hoof, Johan ;

Struyf, Frank ;

Douoguih, Macaya .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (23) :2187-2201

[45] Weight Gain Following Initiation of Antiretroviral Therapy: Risk Factors in Randomized Comparative Clinical Trials [J].

Sax, Paul E. ;

Erlandson, Kristine M. ;

Lake, Jordan E. ;

Mccomsey, Grace A. ;

Orkin, Chloe ;

Esser, Stefan ;

Brown, Todd T. ;

Rockstroh, Jurgen K. ;

Wei, Xuelian ;

Carter, Christoph C. ;

Zhong, Lijie ;

Brainard, Diana M. ;

Melbourne, Kathleen ;

Das, Moupali ;

Stellbrink, Hans-Jurgen ;

Post, Frank A. ;

Waters, Laura ;

Koethe, John R. .

CLINICAL INFECTIOUS DISEASES, 2020, 71 (06) :1379-1389

[46] Patterns of drug use and HIV infection among adults in a nationally representative sample [J].

Shiau, Stephanie ;

Arpadi, Stephen M. ;

Yin, Michael T. ;

Martins, Silvia S. .

ADDICTIVE BEHAVIORS, 2017, 68 :39-44

[47] Efficacy of NVX-CoV2373 Covid-19 Vaccine against the B.1.351 Variant [J].

Shinde, V. ;

Bhikha, S. ;

Hoosain, Z. ;

Archary, M. ;

Bhorat, Q. ;

Fairlie, L. ;

Lalloo, U. ;

Masilela, M. S. L. ;

Moodley, D. ;

Hanley, S. ;

Fouche, L. ;

Louw, C. ;

Tameris, M. ;

Singh, N. ;

Goga, A. ;

Dheda, K. ;

Grobbelaar, C. ;

Kruger, G. ;

Carrim-Ganey, N. ;

Baillie, V. ;

de Oliveira, T. ;

Koen, A. Lombard ;

Lombaard, J. J. ;

Mngqibisa, R. ;

Bhorat, A. E. ;

Benade, G. ;

Lalloo, N. ;

Pitsi, A. ;

Vollgraaff, P. -L. ;

Luabeya, A. ;

Esmail, A. ;

Petrick, F. G. ;

Oommen-Jose, A. ;

Foulkes, S. ;

Ahmed, K. ;

Thombrayil, A. ;

Fries, L. ;

Cloney-Clark, S. ;

Zhu, M. ;

Bennett, C. ;

Albert, G. ;

Faust, E. ;

Plested, J. S. ;

Robertson, A. ;

Neal, S. ;

Cho, I. ;

Glenn, G. M. ;

Dubovsky, F. ;

Madhi, S. A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (20) :1899-1909

[48] Differences in Post-mRNA Vaccination Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Immunoglobulin G (IgG) Concentrations and Surrogate Virus Neutralization Test Response by Human Immunodeficiency Virus (HIV) Status and Type of Vaccine: A Matched Case-Control Observational Study [J].

Spinelli, Matthew A. ;

Peluso, Michael J. ;

Lynch, Kara L. ;

Yun, Cassandra ;

Glidden, David, V ;

Henrich, Timothy J. ;

Deeks, Steven G. ;

Gandhi, Monica .

CLINICAL INFECTIOUS DISEASES, 2022, 75 (01) :E916-E919

[49]

van den Berg R, 2009, AIDS REV, V11, P157

[50] SARS-CoV-2 and the rheumatology patient: the last 12 months and a boost in the future [J].

Winthrop, Kevin L. ;

Whitley, Richard J. ;

Aletaha, Daniel .

ANNALS OF THE RHEUMATIC DISEASES, 2021, 80 (10) :1249-1251

← 1 2 3 4 5 6 →