A Retrospective Study of the Safety and Immunogenicity of MVC-COV1901 Vaccine for People Living with HIV

被引：4

作者：

Cheng, Shu-Hsing ^{[1
,2
]}

Lien, Chia En ^{[3
,4
]}

Hsieh, Szu-Min ^{[5
,6
]}

Cheng, Chien-Yu ^{[1
,4
]}

Liu, Wang-Da ^{[5
,7
]}

Lo, Ching-Lung ^{[8
,9
]}

Ko, Wen-Chien ^{[8
,9
]}

Chen, Yen-Hsu ^{[10
,11
,12
]}

Huang, Ching-Tai ^{[13
,14
]}

Chang, Hsiao-Ting ^{[15
,16
]}

Hwang, Shinn-Jang ^{[15
,16
]}

Wang, Ning-Chi ^{[17
]}

Liu, Ming-Che ^{[18
,19
]}

Lee, Yu-Lin ^{[20
,21
]}

Tai, I-Chen ^{[3
]}

Estrada, Josue Antonio Garcia ^{[3
]}

Lin, Tzou-Yien ^{[14
,22
]}

Lee, Wen-Sen ^{[23
,24
]}

机构：

[1] Taoyuan Gen Hosp, Dept Infect Dis, Minist Hlth & Welf, Taoyuan 330, Taiwan

[2] Taipei Med Univ, Sch Publ Hlth, Taipei 110, Taiwan

[3] Medigen Vaccine Biol, Taipei 114, Taiwan

[4] Natl Yang Ming Chiao Tung Univ, Inst Publ Hlth, Coll Med, Taipei 112, Taiwan

[5] Natl Taiwan Univ Hosp, Dept Internal Med, Div Infect Dis, Taipei 100, Taiwan

[6] Natl Taiwan Univ, Coll Med, Taipei 106, Taiwan

[7] Natl Taiwan Univ, Dept Med, Canc Ctr, Taipei 100, Taiwan

[8] Natl Cheng Kung Univ Hosp, Dept Internal Med, Tainan 704, Taiwan

[9] Natl Cheng Kung Univ, Coll Med, Dept Med, Tainan 701, Taiwan

[10] Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung 807, Taiwan

[11] Kaohsiung Med Univ, Grad Inst Med, Sepsis Res Ctr, Sch Med, Kaohsiung 807, Taiwan

[12] Kaohsiung Med Univ, Ctr Trop Med & Infect Dis, Kaohsiung 807, Taiwan

[13] Chang Gung Mem Hosp, Dept Infect Dis, Taoyuan 333, Taiwan

[14] Chang Gung Univ, Coll Med, Taoyuan 333, Taiwan

[15] Taipei Vet Gen Hosp, Dept Family Med, Taipei 112, Taiwan

[16] Natl Yang Ming Chiao Tung Univ, Sch Med, Taipei 112, Taiwan

[17] Triserv Gen Hosp, Taipei 114, Taiwan

[18] Taipei Med Univ Hosp, Clin Res Ctr, Taipei 110, Taiwan

[19] Taipei Med Univ, Coll Oral Med, Sch Dent Technol, Taipei 110, Taiwan

[20] Changhua Christian Hosp, Dept Internal Med, Changhua 500, Taiwan

[21] Natl Chung Hsing Univ, Program Med Biotechnol, Taichung 402, Taiwan

[22] Chang Gung Mem Hosp, Dept Paediat, Taoyuan 333, Taiwan

[23] Taipei Med Univ, Wan Fang Hosp, Dept Internal Med, Div Infect Dis, Taipei 116, Taiwan

[24] Taipei Med Univ, Coll Med, Sch Med, Dept Internal Med, Taipei 110, Taiwan

来源：

VACCINES | 2023年 / 11卷 / 01期

关键词：

COVID-19; vaccine; CpG; 1018; S-2P protein; HIV; CD4; CD8; ratio; immunogenicity; HUMAN-IMMUNODEFICIENCY-VIRUS; HEPATITIS-B VACCINATION; T-CELL DIFFERENTIATION; ANTIBODY-RESPONSE; COVID-19; VACCINE; MESSENGER-RNA; SARS-COV-2; INFECTION; NUMBER; ADULTS;

D O I：

10.3390/vaccines11010018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: This study aimed to assess the safety and immunogenicity of MVC-COV1901, a recombinant COVID-19 protein vaccine, containing S-2P protein adjuvanted with CpG 1018 and aluminum hydroxide, for people living with HIV (PWH). Methods: A total of 57 PWH of >= 20 years of age who are on stable antiretroviral therapy were compared with 882 HIV-negative participants. Participants received two doses of MVC-COV1901 28 days apart. Results: No vaccine-related serious adverse events (SAEs) were recorded. Seroconversion rates (SCRs) of 100% and 99.8% were achieved in PWH and comparators, respectively, 28 days after the second dose. After adjusting for sex, age, BMI category, and comorbidity, the adjusted GMT ratio of comparator/PWH was 3.2 (95% CI 2.5-4). A higher CD4/CD8 ratio was associated with a higher GMT (R = 0.27, p = 0.039). MVC-COV1901 has shown robust safety but elicited weaker immune responses in PWH. Conclusions: Further investigations may be needed to determine whether PWH require distinct immunization strategies with improved immunogenicity. The main study is registered at ClinicalTrials.gov (NCT04695652).

引用

页数：14

共 58 条

[1] CD4/CD8 Ratio and KT Ratio Predict Yellow Fever Vaccine Immunogenicity in HIV-Infected Patients [J].

Avelino-Silva, Vivian I. ;

Miyaji, Karina T. ;

Hunt, Peter W. ;

Huang, Yong ;

Simoes, Marisol ;

Lima, Sheila B. ;

Freire, Marcos S. ;

Caiaffa-Filho, Helio H. ;

Hong, Marisa A. ;

Costa, Dayane Alves ;

Dias, Juliana Zanatta C. ;

Cerqueira, Natalia B. ;

Nishiya, Anna Shoko ;

Sabino, Ester Cerdeira ;

Sartori, Ana M. ;

Kallas, Esper G. .

PLOS NEGLECTED TROPICAL DISEASES, 2016, 10 (12)

[2] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].

Baden, Lindsey R. ;

El Sahly, Hana M. ;

Essink, Brandon ;

Kotloff, Karen ;

Frey, Sharon ;

Novak, Rick ;

Diemert, David ;

Spector, Stephen A. ;

Rouphael, Nadine ;

Creech, C. Buddy ;

McGettigan, John ;

Khetan, Shishir ;

Segall, Nathan ;

Solis, Joel ;

Brosz, Adam ;

Fierro, Carlos ;

Schwartz, Howard ;

Neuzil, Kathleen ;

Corey, Larry ;

Gilbert, Peter ;

Janes, Holly ;

Follmann, Dean ;

Marovich, Mary ;

Mascola, John ;

Polakowski, Laura ;

Ledgerwood, Julie ;

Graham, Barney S. ;

Bennett, Hamilton ;

Pajon, Rolando ;

Knightly, Conor ;

Leav, Brett ;

Deng, Weiping ;

Zhou, Honghong ;

Han, Shu ;

Ivarsson, Melanie ;

Miller, Jacqueline ;

Zaks, Tal .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416

[3] Influenza vaccination in immunocompromised populations: Strategies to improve immunogenicity [J].

Caldera, Freddy ;

Mercer, Monica ;

Samson, Sandrine, I ;

Pitt, Jonathan M. ;

Hayney, Mary S. .

VACCINE, 2021, 39 :A15-A23

[4] Coronavirus disease 2019 vaccine effectiveness among a population-based cohort of people living with HIV [J].

Chambers, Catharine ;

Samji, Hasina ;

Cooper, Curtis L. ;

Costiniuk, Cecilia T. ;

Janjua, Naveed Z. ;

Kroch, Abigail E. ;

Arbess, Gordon ;

Benoit, Anita C. ;

Buchan, Sarah A. ;

Chung, Hannah ;

Kendall, Claire E. ;

Kwong, Jeffrey C. ;

Langlois, Marc-Andre ;

Lee, Samantha M. ;

Mbuagbaw, Lawrence ;

McCullagh, John ;

Moineddin, Rahim ;

Nambiar, Devan ;

Walmsley, Sharon ;

Anis, Aslam H. ;

Burchell, Ann N. .

AIDS, 2022, 36 (15) :F17-F26

[5] T cell responses in patients with COVID-19 [J].

Chen, Zeyu ;

John Wherry, E. .

NATURE REVIEWS IMMUNOLOGY, 2020, 20 (09) :529-536

[6] Serologic response to hepatitis B vaccine with high dose and increasing number of injections in HIV infected adult patients [J].

Cruciani, Mario ;

Mengoli, Carlo ;

Serpelloni, Giovanni ;

Lanza, Andrea ;

Gomma, Maurizio ;

Nardia, Stefano ;

Rimondo, Claudia ;

Bricolo, Francesco ;

Consolaro, Sandro ;

Trevisan, MariaTeresa ;

Bosco, Oliviero .

VACCINE, 2009, 27 (01) :17-22

[7] Characteristics, Comorbidities, and Outcomes in a Multicenter Registry of Patients With Human Immunodeficiency Virus and Coronavirus Disease 2019 [J].

Dandachi, Dima ;

Geiger, Grant ;

Montgomery, Mary W. ;

Karmen-Tuohy, Savannah ;

Golzy, Mojgan ;

Antar, Annukka A. R. ;

Llibre, Josep M. ;

Camazine, Maraya ;

Diaz-De Santiago, Alberto ;

Carlucci, Philip M. ;

Zacharioudakis, Ioannis M. ;

Rahimian, Joseph ;

Wanjalla, Celestine N. ;

Slim, Jihad ;

Arinze, Folasade ;

Kratz, Ann Marie Porreca ;

Jones, Joyce L. ;

Patel, Shital M. ;

Kitchell, Ellen ;

Francis, Adero ;

Ray, Manoj ;

Koren, David E. ;

Baddley, John W. ;

Hill, Brannon ;

Sax, Paul E. ;

Chow, Jeremy .

CLINICAL INFECTIOUS DISEASES, 2021, 73 (07) :E1964-E1972

[8] Prevention and Treatment of SARS-CoV2 Infection in People Living with HIV: The Need for Specific Data [J].

Diaz, Natalia A. ;

de Miguel, Rosa ;

Aguero, Fernando ;

Sued, Omar ;

Arribas, Jose R. ;

Ambrosioni, Juan .

INFECTIOUS DISEASES AND THERAPY, 2022, 11 (01) :1-13

[9]

Done E., 2020, COVID 19 DASHBOARD C

[10] Weight gain and integrase inhibitors [J].

Eckard, Allison Ross ;

McComsey, Grace A. .

CURRENT OPINION IN INFECTIOUS DISEASES, 2020, 33 (01) :10-19

← 1 2 3 4 5 6 →