A Retrospective Study of the Safety and Immunogenicity of MVC-COV1901 Vaccine for People Living with HIV

被引：4

作者：

Cheng, Shu-Hsing ^{[1
,2
]}

Lien, Chia En ^{[3
,4
]}

Hsieh, Szu-Min ^{[5
,6
]}

Cheng, Chien-Yu ^{[1
,4
]}

Liu, Wang-Da ^{[5
,7
]}

Lo, Ching-Lung ^{[8
,9
]}

Ko, Wen-Chien ^{[8
,9
]}

Chen, Yen-Hsu ^{[10
,11
,12
]}

Huang, Ching-Tai ^{[13
,14
]}

Chang, Hsiao-Ting ^{[15
,16
]}

Hwang, Shinn-Jang ^{[15
,16
]}

Wang, Ning-Chi ^{[17
]}

Liu, Ming-Che ^{[18
,19
]}

Lee, Yu-Lin ^{[20
,21
]}

Tai, I-Chen ^{[3
]}

Estrada, Josue Antonio Garcia ^{[3
]}

Lin, Tzou-Yien ^{[14
,22
]}

Lee, Wen-Sen ^{[23
,24
]}

机构：

[1] Taoyuan Gen Hosp, Dept Infect Dis, Minist Hlth & Welf, Taoyuan 330, Taiwan

[2] Taipei Med Univ, Sch Publ Hlth, Taipei 110, Taiwan

[3] Medigen Vaccine Biol, Taipei 114, Taiwan

[4] Natl Yang Ming Chiao Tung Univ, Inst Publ Hlth, Coll Med, Taipei 112, Taiwan

[5] Natl Taiwan Univ Hosp, Dept Internal Med, Div Infect Dis, Taipei 100, Taiwan

[6] Natl Taiwan Univ, Coll Med, Taipei 106, Taiwan

[7] Natl Taiwan Univ, Dept Med, Canc Ctr, Taipei 100, Taiwan

[8] Natl Cheng Kung Univ Hosp, Dept Internal Med, Tainan 704, Taiwan

[9] Natl Cheng Kung Univ, Coll Med, Dept Med, Tainan 701, Taiwan

[10] Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung 807, Taiwan

[11] Kaohsiung Med Univ, Grad Inst Med, Sepsis Res Ctr, Sch Med, Kaohsiung 807, Taiwan

[12] Kaohsiung Med Univ, Ctr Trop Med & Infect Dis, Kaohsiung 807, Taiwan

[13] Chang Gung Mem Hosp, Dept Infect Dis, Taoyuan 333, Taiwan

[14] Chang Gung Univ, Coll Med, Taoyuan 333, Taiwan

[15] Taipei Vet Gen Hosp, Dept Family Med, Taipei 112, Taiwan

[16] Natl Yang Ming Chiao Tung Univ, Sch Med, Taipei 112, Taiwan

[17] Triserv Gen Hosp, Taipei 114, Taiwan

[18] Taipei Med Univ Hosp, Clin Res Ctr, Taipei 110, Taiwan

[19] Taipei Med Univ, Coll Oral Med, Sch Dent Technol, Taipei 110, Taiwan

[20] Changhua Christian Hosp, Dept Internal Med, Changhua 500, Taiwan

[21] Natl Chung Hsing Univ, Program Med Biotechnol, Taichung 402, Taiwan

[22] Chang Gung Mem Hosp, Dept Paediat, Taoyuan 333, Taiwan

[23] Taipei Med Univ, Wan Fang Hosp, Dept Internal Med, Div Infect Dis, Taipei 116, Taiwan

[24] Taipei Med Univ, Coll Med, Sch Med, Dept Internal Med, Taipei 110, Taiwan

来源：

VACCINES | 2023年 / 11卷 / 01期

关键词：

COVID-19; vaccine; CpG; 1018; S-2P protein; HIV; CD4; CD8; ratio; immunogenicity; HUMAN-IMMUNODEFICIENCY-VIRUS; HEPATITIS-B VACCINATION; T-CELL DIFFERENTIATION; ANTIBODY-RESPONSE; COVID-19; VACCINE; MESSENGER-RNA; SARS-COV-2; INFECTION; NUMBER; ADULTS;

D O I：

10.3390/vaccines11010018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: This study aimed to assess the safety and immunogenicity of MVC-COV1901, a recombinant COVID-19 protein vaccine, containing S-2P protein adjuvanted with CpG 1018 and aluminum hydroxide, for people living with HIV (PWH). Methods: A total of 57 PWH of >= 20 years of age who are on stable antiretroviral therapy were compared with 882 HIV-negative participants. Participants received two doses of MVC-COV1901 28 days apart. Results: No vaccine-related serious adverse events (SAEs) were recorded. Seroconversion rates (SCRs) of 100% and 99.8% were achieved in PWH and comparators, respectively, 28 days after the second dose. After adjusting for sex, age, BMI category, and comorbidity, the adjusted GMT ratio of comparator/PWH was 3.2 (95% CI 2.5-4). A higher CD4/CD8 ratio was associated with a higher GMT (R = 0.27, p = 0.039). MVC-COV1901 has shown robust safety but elicited weaker immune responses in PWH. Conclusions: Further investigations may be needed to determine whether PWH require distinct immunization strategies with improved immunogenicity. The main study is registered at ClinicalTrials.gov (NCT04695652).

引用

页数：14

共 58 条

[1] CD4/CD8 Ratio and KT Ratio Predict Yellow Fever Vaccine Immunogenicity in HIV-Infected Patients
Avelino-Silva, Vivian I.
Miyaji, Karina T.
Hunt, Peter W.
Huang, Yong
Simoes, Marisol
Lima, Sheila B.
Freire, Marcos S.
Caiaffa-Filho, Helio H.
Hong, Marisa A.
Costa, Dayane Alves
Dias, Juliana Zanatta C.
Cerqueira, Natalia B.
Nishiya, Anna Shoko
Sabino, Ester Cerdeira
Sartori, Ana M.
Kallas, Esper G.
[J]. PLOS NEGLECTED TROPICAL DISEASES, 2016, 10 (12):
[2] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine
Baden, Lindsey R.
El Sahly, Hana M.
Essink, Brandon
Kotloff, Karen
Frey, Sharon
Novak, Rick
Diemert, David
Spector, Stephen A.
Rouphael, Nadine
Creech, C. Buddy
McGettigan, John
Khetan, Shishir
Segall, Nathan
Solis, Joel
Brosz, Adam
Fierro, Carlos
Schwartz, Howard
Neuzil, Kathleen
Corey, Larry
Gilbert, Peter
Janes, Holly
Follmann, Dean
Marovich, Mary
Mascola, John
Polakowski, Laura
Ledgerwood, Julie
Graham, Barney S.
Bennett, Hamilton
Pajon, Rolando
Knightly, Conor
Leav, Brett
Deng, Weiping
Zhou, Honghong
Han, Shu
Ivarsson, Melanie
Miller, Jacqueline
Zaks, Tal
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) : 403 - 416
[3] Influenza vaccination in immunocompromised populations: Strategies to improve immunogenicity
Caldera, Freddy
Mercer, Monica
Samson, Sandrine, I
Pitt, Jonathan M.
Hayney, Mary S.
[J]. VACCINE, 2021, 39 : A15 - A23
[4] Coronavirus disease 2019 vaccine effectiveness among a population-based cohort of people living with HIV
Chambers, Catharine
Samji, Hasina
Cooper, Curtis L.
Costiniuk, Cecilia T.
Janjua, Naveed Z.
Kroch, Abigail E.
Arbess, Gordon
Benoit, Anita C.
Buchan, Sarah A.
Chung, Hannah
Kendall, Claire E.
Kwong, Jeffrey C.
Langlois, Marc-Andre
Lee, Samantha M.
Mbuagbaw, Lawrence
McCullagh, John
Moineddin, Rahim
Nambiar, Devan
Walmsley, Sharon
Anis, Aslam H.
Burchell, Ann N.
[J]. AIDS, 2022, 36 (15) : F17 - F26
[5] T cell responses in patients with COVID-19
Chen, Zeyu
John Wherry, E.
[J]. NATURE REVIEWS IMMUNOLOGY, 2020, 20 (09) : 529 - 536
[6] Serologic response to hepatitis B vaccine with high dose and increasing number of injections in HIV infected adult patients
Cruciani, Mario
Mengoli, Carlo
Serpelloni, Giovanni
Lanza, Andrea
Gomma, Maurizio
Nardia, Stefano
Rimondo, Claudia
Bricolo, Francesco
Consolaro, Sandro
Trevisan, MariaTeresa
Bosco, Oliviero
[J]. VACCINE, 2009, 27 (01) : 17 - 22
[7] Characteristics, Comorbidities, and Outcomes in a Multicenter Registry of Patients With Human Immunodeficiency Virus and Coronavirus Disease 2019
Dandachi, Dima
Geiger, Grant
Montgomery, Mary W.
Karmen-Tuohy, Savannah
Golzy, Mojgan
Antar, Annukka A. R.
Llibre, Josep M.
Camazine, Maraya
Diaz-De Santiago, Alberto
Carlucci, Philip M.
Zacharioudakis, Ioannis M.
Rahimian, Joseph
Wanjalla, Celestine N.
Slim, Jihad
Arinze, Folasade
Kratz, Ann Marie Porreca
Jones, Joyce L.
Patel, Shital M.
Kitchell, Ellen
Francis, Adero
Ray, Manoj
Koren, David E.
Baddley, John W.
Hill, Brannon
Sax, Paul E.
Chow, Jeremy
[J]. CLINICAL INFECTIOUS DISEASES, 2021, 73 (07) : E1964 - E1972
[8] Prevention and Treatment of SARS-CoV2 Infection in People Living with HIV: The Need for Specific Data
Diaz, Natalia A.
de Miguel, Rosa
Aguero, Fernando
Sued, Omar
Arribas, Jose R.
Ambrosioni, Juan
[J]. INFECTIOUS DISEASES AND THERAPY, 2022, 11 (01) : 1 - 13
[9] Done E., 2020, COVID 19 DASHBOARD C
[10] Weight gain and integrase inhibitors
Eckard, Allison Ross
McComsey, Grace A.
[J]. CURRENT OPINION IN INFECTIOUS DISEASES, 2020, 33 (01) : 10 - 19

← 1 2 3 4 5 6 →