Effects of frailty, geriatric syndromes, and comorbidity on mortality and quality of life in older adults with HIV

被引：23

作者：

Branas, Fatima ^{[1
]}

Torralba, Miguel ^{[2
]}

Antela, Antonio ^{[3
]}

Vergas, Jorge ^{[4
]}

Ramirez, Margarita ^{[5
]}

Ryan, Pablo ^{[6
]}

Dronda, Fernando ^{[7
]}

Jose Galindo, Maria ^{[8
]}

Machuca, Isabel ^{[9
]}

Jesus Bustinduy, Maria ^{[10
]}

Cabello, Alfonso ^{[11
]}

Luisa Montes, Maria ^{[12
]}

Sanchez-Conde, Matilde ^{[7
]}

机构：

[1] Univ Complutense, Fdn Invest & Innovac Biomed HU Infanta Leonor & H, Hosp Univ Infanta Leonor, Geriatr Dept, Madrid, Spain

[2] Univ Alcala, Hosp Univ Guadalajara, Internal Med Dept, Guadalajara, Spain

[3] Univ Santiago de Compostela, Hosp Clin, Infect Dis Unit, Madrid, Spain

[4] Hosp Univ Clin San Carlos, Internal Med Infect Dis Dept, Madrid, Spain

[5] Hosp Gen Univ Gregorio Maranon, Infect Dis Unit, Madrid, Spain

[6] Univ Complutense, Fdn Invest & Innovac Biomed HU Infanta Leonor & H, Hosp Univ Infanta Leonor, HIV Clin,CIBERINFEC, Madrid, Spain

[7] Hosp Univ Ramon y Cajal, IRYCIS, CIBERINFEC, Infect Dis Dept, Madrid, Spain

[8] Hosp Univ Clin Valencia, Internal Med Infect Dis Dept, Valencia, Spain

[9] Hosp Univ Reina Sofia, Infect Dis Dept, Cordoba, Spain

[10] Hosp Donostia, Infect Dis Dept, San Sebastian, Spain

[11] Fdn Jimenez Diaz, Infect Dis Dept, Madrid, Spain

[12] Hosp Univ La Paz IdiPAZ, Internal Med Dept, HIV Unit, Madrid, Spain

来源：

BMC GERIATRICS | 2023年 / 23卷 / 01期

关键词：

HIV; Frailty; Geriatric syndromes; Mortality; Quality of life; MONTREAL COGNITIVE ASSESSMENT; PHYSICAL FUNCTION; PEOPLE; INFECTION; INFLAMMATION; IMPAIRMENT; DEMENTIA;

D O I：

10.1186/s12877-022-03719-8

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background: To understand the effects of frailty, geriatric syndromes, and comorbidity on quality of life and mortality in older adults with HIV (OAWH).Methods: Cross-sectional study of the FUNCFRAIL multicenter cohort. The setting was outpatient HIV-Clinic. OAWH, 50 year or over were included. We recorded sociodemographic data, HIV infection-related data, comorbidity, frailty, geriatric syndromes (depression, cognitive impairment, falls and malnutrition), quality of life (QOL) and the estimated risk of all-cause 5-year mortality by VACS Index. Association of frailty with geriatric syndromes and comorbidity was evaluated using the Cochran-Mantel-Haenszel test.Results: Seven hundred ninety six patients were included. 24.7% were women, mean age was 58.2 (6.3). 14.7% were 65 or over. 517 (65%) patients had >= 3 comorbidities, >= 1 geriatric syndrome and/or frailty. There were significant dif-ferences in the estimated risk of mortality [(frailty 10.8%) vs. (>= 3 comorbidities 8.2%) vs. (>= 1 geriatric syndrome 8.2%) vs. (nothing 6.2%); p = 0.01] and in the prevalence of fair or poor QOL [(frailty 71.7%) vs. (>= 3 comorbidities 52%) vs. (>= 1 geriatric syndrome 58.4%) vs. (nothing 51%); p = 0.01]. Cognitive impairment was significantly associated to mortal-ity (8.7% vs. 6.2%; p = 0.02) and depression to poor QOL [76.5% vs. 50%; p = 0.01].Conclusions: Frailty, geriatric syndromes, and comorbidity had negative effects on mortality and QOL, but frailty had the greatest negative effect out of the three factors. Our results should be a wake-up call to standardize the screening for frailty and geriatric syndromes in OAWH in the clinical practice.

引用

页数：10