Validation of Mitra® VAMS® as a blood collection technique for trace elements analysis using ICP-MS/MS

被引：2

作者：

Breton, Anthony ^{[1
,2
]}

Cirtiu, Ciprian Mihai ^{[1
,2
]}

Muehlethaler, Cyril ^{[2
]}

Rudge, James ^{[3
]}

Fleury, Normand ^{[1
]}

机构：

[1] Inst Natl Sante Publ Quebec INSPQ, Ctr Toxicol Quebec CTQ, 945 Wolfe, Quebec City, PQ G1V 5B3, Canada

[2] Univ Quebec Trois Rivieres UQTR, Dept Chem Biochem & Phys, 3351 Boul Forges, Quebec City, PQ G9A 5H7, Canada

[3] Crownhill Business Ctr, Trajan Sci & Med, 14 Vincent Ave, Milton Keynes MK8 0AB, England

来源：

BIOANALYSIS | 2024年 / 16卷 / 04期

关键词：

ICP-MS/MS; Method development and validation; Trace elements; VAMS; volumetric absorptive microsampling; whole blood; WHOLE-BLOOD; MICROSAMPLING TECHNIQUES; METABOLOMICS; PLASMA; METAL;

D O I：

10.4155/bio-2023-0180

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Clinical dosage of toxic and essential elements in blood is well established and the collection method is still by venipuncture. This method has drawbacks and is not suited for everyone. Volumetric absorptive microsampling (VAMS) has been shown to have advantages over venipuncture. Materials & methods: Using inductively coupled plasma tandem mass spectrometry, a method for quantifying elements in whole blood sampled on VAMS was developed/validated. Method's performance was assessed by comparison with whole blood results. Results: Validation and performance assessment tests tend to show that most of the targeted elements provides accurate and reproducible results comparing to a method of reference. Conclusion: Overall, VAMS presents good preliminary results to eventually become an alternative to venipuncture for blood sampling for some trace elements analysis purposes.

引用

页码：203 / 217

页数：16

共 39 条

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