Synthesis and cytotoxic activity of N-[(alkylsulfanyl)methyl]- and N-[(arylsulfanyl)methyl]benzamides

被引：1

作者：

Khairullina, R. R. ^{[1
]}

Kuzmina, U. Sh. ^{[2
]}

Yakupova, L. R. ^{[1
]}

Vakhitova, Yu. V. ^{[2
]}

机构：

[1] Russian Acad Sci, Inst Petrochem & Catalysis, Ufa Fed Res Ctr, 141 Prosp Oktyabrya, Ufa 450075, Russia

[2] Russian Acad Sci, Inst Biochem & Genet, Ufa Fed Res Ctr, 71 Prosp Oktyabrya, Ufa 450054, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2023年 / 72卷 / 10期

关键词：

thiomethylation; aminobenzamides; thiols; paraformaldehyde; N-[(alkylsulfanyl)methyl]benzamides; N-[(arylsulfanyl)methyl]benzamides; cytotoxic activity; catalysis; TARGETED DRUG-DELIVERY; CATALYTIC THIOMETHYLATION; DERIVATIVES; POTENT; BIS(N; N-DIMETHYLAMINO)METHANE; 2-AMINOBENZAMIDE; ACTIVATOR;

D O I：

10.1007/s11172-023-4052-2

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A catalytic approach for the synthesis of N-[(alkylsulfanyl)methyl]- and N-[(arylsulfanyl)methyl]benzamides was developed via thiomethylation of 2-, 3- and 4-aminobenzamides with alkylthio- or arylthiomethanols. A moderate cytotoxic activity of 4-s[(heptylthio)methyl]aminobenzamide was established against a number of cell lines, with the most pronounced effect against the Jurkat leukemic T-cell line.

引用

页码：2501 / 2507

页数：7

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