It Is All about Probiotics to Control Cervical Cancer

被引:5
作者
Ashique, Sumel [1 ]
Faruk, Abdul [2 ]
Ahmad, Farhan Jalees [3 ]
Khan, Tasneem [3 ]
Mishra, Neeraj [4 ]
机构
[1] Sch Pharm, Dept Pharmaceut, Pandaveswar 713346, West Bengal, India
[2] Hemwati Nandan Bahuguna Garhwal Univ, Dept Pharmaceut Sci, Srinagar, Uttarakhand, India
[3] Jamia Hamdard, Sch Pharmaceut Educ & Res SPER, Dept Pharmaceut, New Delhi 110062, India
[4] Amity Univ, Amity Inst Pharm, Gwalior 474005, Madhya Pradesh, India
关键词
Cervical cancer; HPV; Probiotics; ROS; Cisplatin; Microbiota; MANGANESE SUPEROXIDE-DISMUTASE; LACTIC-ACID BACTERIA; LACTOBACILLUS-ACIDOPHILUS; DOUBLE-BLIND; VAGINAL MICROBIOTA; HPV INFECTION; ANTICANCER; PREVENTION; IMPACT; ASSOCIATION;
D O I
10.1007/s12602-023-10183-2
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Cervical cancer (CC) is the fourth most common malignancy in female patients. "Human papillomavirus" (HPV) contamination is a leading cause of all forms of cervical cancer, accounting for an expected 570,000 reported incidents in 2018. Two HPV strains (16 and 18) are responsible for 70% of CC and pre-cancerous cervical abnormalities. CC is one of the foremost reasons for the malignancy death rate in India among women ranging from 30 to 69 years of age in India, responsible for 17% of all cancer deaths. Currently approved cervical cancer treatments are associated with adverse reactions that might harm the lives of women affected by this disease. Consequently, probiotics can play a vital role in the treatment of CC. It is reflected from various studies regarding the role of probiotics in the diagnosis, prevention or treatment of cancer. In this review article, we have discussed the rationale of probiotics for treatment of CC, the role of probiotics as effective adjuvants in anti-cancer therapy and the combined effect of the anti-cancer drug along with probiotics to minimize the side effects due to chemotherapy.
引用
收藏
页码:979 / 992
页数:14
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