Neoadjuvant Chemoradiation Followed by Surgery for Locally Advanced Squamous Cell Carcinoma Esophagus: Demographics and Evaluation of Prognostic Factors at a Tertiary Care Center in India

被引：0

作者：

Mithi, Mohamed Taher ^{[1
]}

Sharma, Mohit ^{[1
]}

Puj, Ketul ^{[1
]}

Hazarika, Prandweep ^{[1
]}

Pandya, Shashank J. ^{[1
]}

Gandhi, Jahnavi ^{[2
]}

Parikh, Ankita ^{[3
]}

Shukla, Shivang ^{[1
]}

机构：

[1] Gujarat Canc Res Inst, Dept Surg Oncol, Ahmadabad 380016, Gujarat, India

[2] Gujarat Canc Res Inst, Dept Pathol, Ahmadabad 380016, Gujarat, India

[3] Gujarat Canc Res Inst, Dept Radiotherapy, Ahmadabad 380016, Gujarat, India

来源：

INDIAN JOURNAL OF SURGICAL ONCOLOGY | 2024年 / 15卷 / 01期

关键词：

Esophageal cancer; Neoadjuvant chemoradiation; Pathological complete response; Squamous cell carcinoma; Esophagectomy; PATHOLOGICAL COMPLETE RESPONSE; ADVANCED RESECTABLE CARCINOMA; WALL THICKNESS; SINGLE-CENTER; CHEMORADIOTHERAPY; SURVIVAL; CANCER; TRENDS;

D O I：

10.1007/s13193-023-01828-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neoadjuvant chemoradiation followed by surgery has been the standard of care for locally advanced carcinoma esophagus. We present our experience and inference of various factors associated with the same treatment and the prognostic influence of the same. A retrospective analysis of a cohort of 132 squamous cell carcinoma esophagus patients post neoadjuvant chemoradiation operated with curative intent was carried out. The 2-year overall survival rate was 64.5%. A pathological complete response was achieved in 32.5% of patients and was the only factor that significantly determined overall survival (p = 0.048). Neoadjuvant chemoradiation before surgery for locally advanced squamous cell cancer of the esophagus remains the standard of care with a pathological complete response being a significant factor in predicting overall survival. More prospective randomized studies are necessary to analyze factors affecting and predicting a pathological complete response which would help organ preservation in patients with a complete response.

引用

页码：129 / 135

页数：7

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