Multifunctional Hydrogels for the Healing of Diabetic Wounds

被引:97
作者
Xiang, Tao [1 ,2 ]
Guo, Qianru [1 ,2 ]
Jia, Lianghao [1 ,2 ]
Yin, Tianyu [1 ,2 ]
Huang, Wei [1 ,2 ]
Zhang, Xinyu [1 ,2 ]
Zhou, Shaobing [1 ,2 ]
机构
[1] Southwest Jiaotong Univ, Inst Biomed Engn, Coll Med, Chengdu 610031, Sichuan, Peoples R China
[2] Southwest Jiaotong Univ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat, Minist Educ, Chengdu 610031, Peoples R China
基金
中国国家自然科学基金;
关键词
antibacterials; anti-inflammatories; diabetic wounds; hydrogels; immunomodulatory; injectable self-healing; pro-angiogenics; SHAPE-MEMORY HYDROGEL; HYALURONIC-ACID HYDROGELS; IRON-OXIDE NANOPARTICLES; INJECTABLE HYDROGELS; EXTRACELLULAR-MATRIX; CHITOSAN HYDROGEL; BIOMEDICAL APPLICATIONS; PROMOTING ANGIOGENESIS; ANTIMICROBIAL ACTIVITY; CARRAGEENAN HYDROGEL;
D O I
10.1002/adhm.202301885
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The healing of diabetic wounds is hindered by various factors, including bacterial infection, macrophage dysfunction, excess proinflammatory cytokines, high levels of reactive oxygen species, and sustained hypoxia. These factors collectively impede cellular behaviors and the healing process. Consequently, this review presents intelligent hydrogels equipped with multifunctional capacities, which enable them to dynamically respond to the microenvironment and accelerate wound healing in various ways, including stimuli -responsiveness, injectable self-healing, shape -memory, and conductive and real-time monitoring properties. The relationship between the multiple functions and wound healing is also discussed. Based on the microenvironment of diabetic wounds, antibacterial, anti-inflammatory, immunomodulatory, antioxidant, and pro-angiogenic strategies are combined with multifunctional hydrogels. The application of multifunctional hydrogels in the repair of diabetic wounds is systematically discussed, aiming to provide guidelines for fabricating hydrogels for diabetic wound healing and exploring the role of intelligent hydrogels in the therapeutic processes. Multifunctional hydrogels have great advantages in the treatment of diabetic wounds. This review overviews hydrogels with stimuli-responsive, injectable self-healing, shape-memory, conductive, and real-time monitoring properties for application in treating diabetic wounds through strategies including antibacterial, anti-inflammatory, immunomodulatory, antioxidant, pro-angiogenic, and synergistic effects, providing guidelines for fabricating hydrogels exploring the role of intelligent hydrogels in the therapeutic process.image
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页数:40
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