An Overview of Circulating Biomarkers in Neuroendocrine Neoplasms: A Clinical Guide

被引：16

作者：

Bevere, Michele ^{[1
]}

Masetto, Francesca ^{[1
]}

Carazzolo, Maria Elena ^{[2
]}

Bettega, Alice ^{[2
]}

Gkountakos, Anastasios ^{[1
]}

Scarpa, Aldo ^{[1
,2
]}

Simbolo, Michele ^{[2
]}

机构：

[1] Univ Verona, ARC Net Res Ctr, I-37134 Verona, Italy

[2] Univ & Hosp Trust Verona, Dept Diagnost & Publ Hlth, Sect Pathol, I-37134 Verona, Italy

来源：

DIAGNOSTICS | 2023年 / 13卷 / 17期

关键词：

neuroendocrine neoplasms; circulating biomarkers; liquid biopsy; mono-analyte biomarkers; multi-analyte biomarkers; diagnostic biomarkers; predictive biomarkers of treatment response; disease monitoring biomarkers; NEURON-SPECIFIC ENOLASE; PLASMA CHROMOGRANIN-A; TUMOR-CELLS; FOLLOW-UP; PANCREATIC-POLYPEPTIDE; PROGNOSTIC MARKERS; LIQUID BIOPSY; TRANSCRIPT ANALYSIS; PREDICTS SURVIVAL; DIAGNOSIS;

D O I：

10.3390/diagnostics13172820

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Neuroendocrine neoplasms (NENs) are a heterogeneous group of diseases that are characterized by different behavior and clinical manifestations. The diagnosis and management of this group of tumors are challenging due to tumor complexity and lack of precise and widely validated biomarkers. Indeed, the current circulating mono-analyte biomarkers (such as chromogranin A) are ineffective in describing such complex tumors due to their poor sensitivity and specificity. In contrast, multi-analytical circulating biomarkers (including NETest) are emerging as more effective tools to determine the real-time profile of the disease, both in terms of accurate diagnosis and effective treatment. In this review, we will analyze the capabilities and limitations of different circulating biomarkers focusing on three relevant questions: (1) accurate and early diagnosis; (2) monitoring of disease progression and response to therapy; and (3) detection of early relapse.

引用

页数：20

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