Neuraminidase 4 (NEU4): new biological and physiological player

被引：6
作者：
Okun, Sarah [1 ]
Peek, Allyson [1 ]
Igdoura, Suleiman A. [1 ,2 ,3 ]
机构：
[1] McMaster Univ, Dept Biol, Hamilton, ON L8S 4K1, Canada
[2] McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON L8S 4K1, Canada
[3] McMaster Univ, 1280 Main St W LSB 335, Hamilton, ON L8S 4K1, Canada
来源：
GLYCOBIOLOGY | 2023年 / 33卷 / 03期
基金：
加拿大自然科学与工程研究理事会;
关键词：
sialylation; lysosomes; ganglioside; sialidase; cancer; SIALIDASE NEU4; POLYSIALIC ACID; EXPRESSION; GANGLIOSIDE; CELLS; GD3; IDENTIFICATION; MEMBRANE; FAMILY; BRAIN;
D O I：
10.1093/glycob/cwad008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Sialidases are found in viruses, bacteria, fungi, avians, and mammals. Mammalian sialidases differ in their specificity, optimum pH, subcellular localization, and tissue expression. To date, four genes encoding mammalian sialidases (NEU1-4) have been cloned. This review examines the functional impact of NEU4 sialidase on complex physiological and cellular processes. The intracellular localization and trafficking of NEU4 and its potential target molecules are discussed along with its impact on cancer, lysosomal storage disease, and cellular differentiation. Modulation of NEU4 expression may be essential not only for the breakdown of sialylated glycoconjugates, but also in the activation or inactivation of functionally important cellular events.
引用
收藏
页码：182 / 187
页数：6
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