Quercetin prevents osteoarthritis progression possibly via regulation of local and systemic inflammatory cascades

被引:18
作者
Wang, Haiyan [1 ,2 ]
Yan, Yongyong [1 ,2 ]
Pathak, Janak L. [1 ]
Hong, Wei [3 ,4 ]
Zeng, Jing [5 ]
Qian, Dongyang [6 ]
Hao, Binwei [3 ,7 ]
Li, Haiqing [3 ]
Gu, Jinlan [4 ]
Jaspers, Richard T. [1 ,2 ]
Wu, Gang [8 ,9 ]
Shao, Ming [10 ]
Peng, Gongyong [3 ]
Lan, Haifeng [10 ]
机构
[1] Guangzhou Med Univ, Affiliated Stomatol Hosp, Guangdong Engn Res Ctr Oral Restorat & Reconstruct, Guangzhou Key Lab Basic & Appl Res Oral Regenerat, Guangzhou, Peoples R China
[2] Vrije Univ Amsterdam, Fac Behav & Movement Sci, Dept Human Movement Sci, Lab Myol,Amsterdam Movement Sci, Amsterdam, Netherlands
[3] Guangzhou Med Univ, Affiliated Hosp 1, Guangzhou Inst Resp Hlth, State Key Lab Resp Dis,Natl Ctr Resp Med,Natl Clin, Guangzhou, Guangdong, Peoples R China
[4] Guangzhou Med Univ, GMU GIBH Joint Sch Life Sci, Guangzhou, Peoples R China
[5] Liwan Cent Hosp Guangzhou, Guangzhou, Peoples R China
[6] Guangzhou Med Univ, Affiliated Hosp 1, Dept Orthopaed, Guangdong Key Lab Orthopaed Technol & Implant Mat, Guangzhou, Peoples R China
[7] Shanxi Acad Med Sci, Shanxi Bethune Hosp, Dept Pulm & Crit Care Med, Taiyuan, Peoples R China
[8] Vrije Univ Amsterdam, Amsterdam UMC, Dept Oral & Maxillofacial Surg Pathol, Amsterdam Movement Sci, Amsterdam, Netherlands
[9] Vrije Univ Amsterdam, Acad Ctr Dent Amsterdam ACTA, Amsterdam Movement Sci, Amsterdam, Netherlands
[10] Guangzhou Med Univ, Affiliated Hosp 3, Dept Orthopaed Surg, Guangzhou, Guangdong, Peoples R China
关键词
inflammation; osteoarthritis; osteochondral degeneration; pro-inflammatory markers; quercetin; IN-VIVO; CARTILAGE; CHONDROCYTES; EXPRESSION; CHEMOKINES; ADAMTS4; MMP-13; RATS;
D O I
10.1111/jcmm.17672
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Due to the lack of effective treatments, osteoarthritis (OA) remains a challenge for clinicians. Quercetin, a bioflavonoid, has shown potent anti-inflammatory effects. However, its effect on preventing OA progression and the underlying mechanisms are still unclear. In this study, Sprague-Dawley male rats were divided into five groups: control group, OA group (monosodium iodoacetate intra-articular injection), and three quercetin-treated groups. Quercetin-treated groups were treated with intragastric quercetin once a day for 28 days. Gross observation and histopathological analysis showed cartilage degradation and matrix loss in the OA group. High-dose quercetin-group joints showed failure in OA progression. High-dose quercetin inhibited the OA-induced expression of MMP-3, MMP-13, ADAMTS4, and ADAMTS5 and promoted the OA-reduced expression of aggrecan and collagen II. Levels of most inflammatory cytokines and growth factors tested in synovial fluid and serum were upregulated in the OA group and these increases were reversed by high-dose quercetin. Similarly, subchondral trabecular bone was degraded in the OA group and this effect was reversed in the high-dose quercetin group. Our findings indicate that quercetin has a protective effect against OA development and progression possibly via maintaining the inflammatory cascade homeostasis. Therefore, quercetin could be a potential therapeutic agent to prevent OA progression in risk groups.
引用
收藏
页码:515 / 528
页数:14
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