Breakthrough SARS-CoV-2 infection and disease flares in patients with rheumatoid arthritis: result from COVAD e-survey study

被引：2

作者：

Santos, Cristiana Sieiro ^{[1
,2
]}

Chen, Jun-Peng ^{[3
]}

Nikiphorou, Elena ^{[4
,5
]}

Tseng, Chi-Wei ^{[6
]}

Gutierrez, Carlos Enrique Toro ^{[7
]}

Tan, Ai Lyn ^{[8
,9
]}

Nune, Arvind ^{[10
]}

Kadam, Esha ^{[11
,12
]}

Kuwana, Masataka ^{[13
]}

Day, Jessica ^{[14
,15
,16
]}

Saha, Sreoshy ^{[17
]}

Velikova, Tsvetelina ^{[18
]}

Lilleker, James B. ^{[19
,20
]}

Caballero-Uribe, Carlo V. ^{[21
]}

Sen, Parikshit ^{[22
]}

Chinoy, Hector ^{[19
,23
,24
]}

Aggarwal, Rohit ^{[25
]}

Agarwal, Vikas ^{[26
]}

Gupta, Latika ^{[19
,27
,28
]}

Chen, Yi-Ming ^{[3
,6
,29
,30
,31
,32
]}

机构：

[1] Complejo Asistencial Univ Leon, Castilla, Spain

[2] Complejo Asistencial Univ Leon, Leon, Spain

[3] Taichung Vet Gen Hosp, Dept Med Res, Taichung, Taiwan

[4] Kings Coll London, Ctr Rheumat Dis, London, England

[5] Kings Coll Hosp London, Dept Rheumatol, London, England

[6] Taichung Vet Gen Hosp, Dept Internal Med, Div Allergy Immunol & Rheumatol, Dept Med Res, Taichung, Taiwan

[7] Pontifica Univ Javeriana, Reference Ctr Osteoporosis Rheumatol & Dermatol, Cali, Colombia

[8] Leeds Teaching Hosp NHS Trust, NIHR Leeds Biomed Res Ctr, Leeds, W Yorkshire, England

[9] Univ Leeds, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, W Yorkshire, England

[10] Southport & Ormskirk Hosp NHS Trust, Southport PR8 6PN, England

[11] Seth Gordhandhas Sunderdas Med Coll, Mumbai, Maharashtra, India

[12] King Edwards Mem Hosp, Mumbai, Maharashtra, India

[13] Nippon Med Sch, Grad Sch Med, Dept Allergy & Rheumatol, 1-1-5 Sendagi,Bunkyo Ku, Tokyo 1138602, Japan

[14] Royal Melbourne Hosp, Dept Rheumatol, Parkville, Vic 3050, Australia

[15] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3052, Australia

[16] Univ Melbourne, Dept Med Biol, Parkville, Vic 3052, Australia

[17] Mymensingh Med Coll, Mymensingh, Bangladesh

[18] Sofia Univ St Kliment Ohridski, Med Fac, 1 Kozyak Str, Sofia 1407, Bulgaria

[19] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth,Ctr Musculoskeletal Res, Sch Biol Sci,Div Musculoskeletal & Dermatol Sci, Manchester, Lancs, England

[20] Salford Royal NHS Fdn Trust, Manchester Ctr Clin Neurosci, Salford, Lancs, England

[21] Hosp Univ Norte, Dept Med, Barranquilla, Atlantico, Colombia

[22] Maulana Azad Med Coll, 2 Bahadurshah Zafar Marg, Delhi 110002, India

[23] Univ Manchester, Manchester Univ NHS Fdn Trust, Natl Inst Hlth Res Manchester Biomed Res Ctr, Manchester, Lancs, England

[24] Northern Care Alliance NHS Fdn Trust, Salford Royal Hosp, Dept Rheumatol, Salford, Lancs, England

[25] Univ Pittsburgh, Sch Med, Div Rheumatol & Clin Immunol, Pittsburgh, PA USA

[26] Sanjay Gandhi Postgrad Inst Med Sci, Dept Clin Immunol & Rheumatol, Lucknow, Uttar Pradesh, India

[27] Royal Wolverhampton Hosp NHS Trust, Dept Rheumatol, Wolverhampton, Stafford, England

[28] Sandwell & West Birmingham Hosp NHS Trust, City Hosp, Dept Rheumatol, Birmingham, Warwick, England

[29] Taichung Vet Gen Hosp, Dept Med Res, Div Allergy Immunol & Rheumatol, Taichung, Taiwan

[30] Natl Chung Hsing Univ, Coll Med, Dept Postbaccalaureate Med, Taichung, Taiwan

[31] Natl Chung Hsing Univ, Coll Med, Precis Med Res Ctr, Taichung, Taiwan

[32] Natl Yang Ming Chiao Tung Univ, Sch Med, Taipei, Taiwan

来源：

RHEUMATOLOGY INTERNATIONAL | 2024年 / 44卷 / 05期

关键词：

COVID-19; Rheumatoid arthritis; Breakthrough infection; Disease flares;

D O I：

10.1007/s00296-024-05542-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

COVID-19 has been suggested as a possible trigger of disease flares in patients with rheumatoid arthritis (RA). However, factors associated with disease flares remain unknown. This study aimed to identify factors associated with breakthrough infection (BIs) and disease flares in patients with RA following COVID-19. We analysed data from RA patients who participated in the COVID-19 vaccination in autoimmune diseases (COVAD) study. Demographic data, patient-reported outcomes, comorbidities, pharmacologic treatment and details regarding disease flares were extracted from the COVAD database. Factors associated with disease flare-ups were determined by multivariate logistic regression analysis. The analysis comprised 1928 patients with RA who participated in the COVAD study. Younger age, Caucasian ethnicity, comorbidities with obstructive chronic pulmonary disease and asthma were associated with COVID-19 breakthrough infection. Moreover, younger age (odds ratio (OR): 0.98, 95% CI 0.96-0.99, p < 0.001), ethnicity other than Asian, past history of tuberculosis (OR: 3.80, 95% CI 1.12-12.94, p = 0.033), treatment with methotrexate (OR: 2.55, 95% CI: 1.56-4.17, p < 0.001), poor global physical health (OR: 1.07, 95% CI 1.00-1.15, p = 0.044) and mental health (OR: 0.91, 95% CI 0.87-0.95, p < 0.001) were independent factors associated disease flares in patients with RA. Our study highlights the impact of socio-demographic factors, clinical characteristics and mental health on disease flares in patients with RA. These insights may help determine relevant strategies to proactively manage RA patients at risk of flares.

引用

页码：863 / 884

页数：22

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