A Glycerol promoted, regioselective synthesis of 6-aryl substituted Imidazo[2,1-b]thiazole and imidazo[2,1-b]-1,3,4-thiadiazole through a one-step domino process under green conditions

被引：1

作者：

Baranwal, Jyoti ^{[1
]}

Kushwaha, Smriti ^{[1
]}

Singh, Swastika ^{[1
]}

机构：

[1] SS Khanna Girls Degree Coll, Dept Chem, Prayagraj, Uttar Pradesh, India

来源：

CHEMISTRYSELECT | 2024年 / 9卷 / 11期

关键词：

Green solvent; green synthesis; imidazo[2,1-b][1,3,4]thiadiazole; imidazo[2,1-b]thiazole; VITRO ANTICANCER EVALUATION; IN-VITRO; BIOLOGICAL EVALUATION; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; CATALYST-FREE; DERIVATIVES; ANTITUMOR; INHIBITORS; DISCOVERY;

D O I：

10.1002/slct.202304043

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this study, we present a strategy for synthesizing Imidazo[2,1-b]thiazole and Imidazo[2,1-b][1,3,4]thiadiazole in a single step with high efficiency. Glycerol is utilized as a sustainable solvent, offering both economic and non-toxic properties to facilitate the selective formation of these compounds. The reaction entails a stepwise formation of C-N bonds. Key benefits of this approach include its environmentally conscious reaction conditions, simplicity in execution, cost-effectiveness, short reaction times, high product yields, solvent reusability, and overall sustainability.

引用

页数：8

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