Evidence for the contribution of the gut microbiome to obesity and its reversal

被引：23

作者：

de Wit, Douwe F. ^{[1
,2
]}

Hanssen, Nordin M. J. ^{[1
]}

Wortelboer, Koen ^{[1
,2
]}

Herrema, Hilde ^{[1
,2
,3
]}

Rampanelli, Elena ^{[1
,2
,4
]}

Nieuwdorp, Max ^{[1
,2
,5
]}

机构：

[1] Amsterdam UMC locat Univ Amsterdam, Expt Vasc Med, NL-1105AZ Amsterdam, Netherlands

[2] Amsterdam Cardiovasc Sci Diabet & Metab, NL-1105AZ Amsterdam, Netherlands

[3] Amsterdam Gastroenterol Endocrinol Metab, NL-1105AZ Amsterdam, Netherlands

[4] Amsterdam Inst Infect & Immun, NL-1105AZ Amsterdam, Netherlands

[5] Amsterdam UMC locat Vrije Univ Med Ctr, Diabet Ctr, Dept Internal Med, NL-1105AZ Amsterdam, Netherlands

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2023年 / 15卷 / 723期

关键词：

RANDOMIZED DOUBLE-BLIND; X RECEPTOR DEFICIENCY; INTESTINAL MICROBIOTA; INSULIN SENSITIVITY; METABOLIC SYNDROME; FECAL MICROBIOTA; GLUCOSE-METABOLISM; DIETARY OBESITY; BILE-ACID; WEIGHT;

D O I：

10.1126/scitranslmed.adg2773

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Obesity has become a worldwide pandemic affecting more than 650 million people and is associated with a high burden of morbidity. Alongside traditional risk factors for obesity, the gut microbiome has been identified as a potential factor in weight regulation. Although rodent studies suggest a link between the gut microbiome and body weight, human evidence for causality remains scarce. In this Review, we postulate that existing evidence remains to establish a contribution of the gut microbiome to the development of obesity in humans but that modified probiotic strains and supraphysiological dosages of microbial metabolites may be beneficial in combatting obesity.

引用

页数：15

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