Melodic maestros: Unraveling the role of miRNAs in the diagnosis, progression, and drug resistance of malignant pleural mesothelioma

被引：23
作者：
Abd-Elmawla, Mai A. [1 ]
Mageed, Sherif S. Abdel [2 ]
AL-Noshokaty, Tohada M. [3 ]
Elballal, Mohammed S. [4 ]
Abulsoud, Ahmed I. [3 ,5 ]
Elshaer, Shereen Saeid [3 ,6 ]
El-Husseiny, Ahmed A. [5 ,7 ]
Fathi, Doaa [3 ]
Midan, Heba M.
Rizk, Nehal I. [3 ]
Elrebehy, Mahmoud A.
Sayed, Ghadir A. [7 ]
Tabaa, Manar Mohammed El [8 ]
Salman, Aya [7 ]
Mohammed, Osama A. [9 ]
Ashraf, Alaa [10 ]
Khidr, Emad Gamil [5 ]
Khaled, Reem [4 ]
El-Dakroury, Walaa A. [11 ]
Helal, Gouda Kamel [12 ,13 ]
Moustafa, Yasser M. [2 ,14 ]
Doghish, Ahmed S. [4 ,5 ]
机构：
[1] Cairo Univ, Fac Pharm, Dept Biochem, Biochem, Cairo, Egypt
[2] Badr Univ Cairo BUC, Fac Pharm, Pharmacol & Toxicol Dept, Cairo 11829, Egypt
[3] Heliopolis Univ, Fac Pharm, Biochem Dept, Cairo 11785, Egypt
[4] Badr Univ Cairo BUC, Fac Pharm, Dept Biochem, Cairo 11829, Egypt
[5] Al Azhar Univ, Fac Pharm Boys, Biochem & Mol Biol Dept, Cairo 11231, Egypt
[6] Al Azhar Univ, Fac Pharm Girls, Dept Biochem, Cairo 11823, Egypt
[7] Egyptian Russian Univ, Fac Pharm, Dept Biochem, Cairo 11829, Egypt
[8] Univ Sadat City, Environm Studies & Res Inst ESRI, Pharmacol & Environm Toxicol, Sadat City 32897, Menoufia, Egypt
[9] Univ Bisha, Coll Med, Dept Clin Pharmacol, Bisha 61922, Saudi Arabia
[10] Badr Univ Cairo BUC, Fac Pharm, Dept Clin Pharm & Pharm Practice, Cairo 11829, Egypt
[11] Badr Univ Cairo BUC, Fac Pharm, Dept Pharmaceut & Ind Pharm, Cairo 11829, Egypt
[12] Al Azhar Univ, Fac Pharm, Dept Pharmacol & Toxicol, Cairo 11231, Egypt
[13] Heliopolis Univ, Fac Pharm, Dept Pharmacol & Toxicol, Cairo 11785, Egypt
[14] Suez Canal Univ, Fac Pharm, Dept Pharmacol & Toxicol, Ismailia 41522, Egypt
来源：
PATHOLOGY RESEARCH AND PRACTICE | 2023年 / 250卷
关键词：
MiRNA; Malignant pleural mesothelioma; MPM; Drug resistance; Diagnosis; Prognosis; EPITHELIAL-MESENCHYMAL TRANSITION; POTENTIAL VEGFR-2 INHIBITORS; CELL-CYCLE ARREST; CISPLATIN RESISTANCE; BREAST-CANCER; TUMOR-GROWTH; MDR1/P-GLYCOPROTEIN EXPRESSION; HEPATOCELLULAR-CARCINOMA; MOLECULAR-MECHANISMS; INDUCE APOPTOSIS;
D O I：
10.1016/j.prp.2023.154817
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Malignant pleural mesothelioma (MPM) is a highly lethal form of pleural cancer characterized by a scarcity of effective therapeutic interventions, resulting in unfavorable prognoses for afflicted individuals. Besides, many patients experience substantial consequences from being diagnosed in advanced stages. The available diagnostic, prognostic, and therapeutic options for MPM are restricted in scope. MicroRNAs (miRNAs) are a subset of small, noncoding RNA molecules that exert significant regulatory influence over several cellular processes within cell biology. A wide range of miRNAs have atypical expression patterns in cancer, serving specific functions as either tumor suppressors or oncomiRs. This review aims to collate, epitomize, and analyze the latest scholarly investigations on miRNAs that are believed to be implicated in the dysregulation leading to MPM. miRNAs are also discussed concerning their potential clinical usefulness as diagnostic and prognostic biomarkers for MPM. The future holds promising prospects for enhancing diagnostic, prognostic, and therapeutic modalities for MPM, with miRNAs emerging as a potential trigger for such advancements.
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页数：20
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共 284 条
  • [1] Interactome battling of lncRNA CCDC144NL-AS1: Its role in the emergence and ferocity of cancer and beyond
    Abd El Fattah, Yasmine K.
    Abulsoud, Ahmed I.
    AbdelHamid, Sherihan G.
    Hamdy, Nadia M.
    [J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2022, 222 : 1676 - 1687
  • [2] miRNAs as potential game-changers in melanoma: A comprehensive review
    Abd-Allah, Gamil M.
    Ismail, Ahmed
    El-Mahdy, Hesham A.
    Elsakka, Elsayed G. E.
    El-Husseiny, Ahmed A.
    Abdelmaksoud, Nourhan M.
    Salman, Aya
    Elkhawaga, Samy Y.
    Doghish, Ahmed S.
    [J]. PATHOLOGY RESEARCH AND PRACTICE, 2023, 244
  • [3] Abdelmaksoud N.M., 2023, Pathol. Res. Pract.
  • [4] Mitochondrial remodeling in colorectal cancer initiation, progression, metastasis, and therapy: A review
    Abdelmaksoud, Nourhan M.
    Abulsoud, Ahmed I.
    Abdelghany, Tamer M.
    Elshaer, Shereen Saeid
    Rizk, Sherine Maher
    Senousy, Mahmoud A.
    [J]. PATHOLOGY RESEARCH AND PRACTICE, 2023, 246
  • [5] The potential role of miRNAs in the pathogenesis of salivary gland cancer - A Focus on signaling pathways interplay
    Abulsoud, Ahmed I.
    Elshaer, Shereen Saeid
    El-Husseiny, Ahmed A.
    Fathi, Doaa
    Abdelmaksoud, Nourhan M.
    Mageed, Sherif S. Abdel
    Salman, Aya
    Zaki, Mohamed Bakr
    El-Mahdy, Hesham A.
    Ismail, Ahmed
    Elsakka, Elsayed G. E.
    Abd-Elmawla, Mai A.
    El-Husseiny, Hussein M.
    Ibrahim, Wael S.
    Doghish, Ahmed S.
    [J]. PATHOLOGY RESEARCH AND PRACTICE, 2023, 247
  • [6] Mutations in SARS-CoV-2: Insights on structure, variants, vaccines, and biomedical interventions
    Abulsoud, Ahmed I.
    El-Husseiny, Hussein M.
    El-Husseiny, Ahmed A.
    El-Mahdy, Hesham A.
    Ismail, Ahmed
    Elkhawaga, Samy Y.
    Khidr, Emad Gamil
    Fathi, Doaa
    Mady, Eman A.
    Najda, Agnieszka
    Algahtani, Mohammad
    Theyab, Abdulrahman
    Alsharif, Khalaf F.
    Albrakati, Ashraf
    Bayram, Roula
    Abdel-Daim, Mohamed M.
    Doghish, Ahmed S.
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2023, 157
  • [7] MicroRNA and mRNA Features of Malignant Pleural Mesothelioma and Benign Asbestos-Related Pleural Effusion
    Ak, Guntulu
    Tomaszek, Sandra C.
    Kosari, Farhad
    Metintas, Muzaffer
    Jett, James R.
    Metintas, Selma
    Yildirim, Huseyin
    Dundar, Emine
    Dong, Jie
    Aubry, Marie Christine
    Wigle, Dennis A.
    Thomas, Charles F., Jr.
    [J]. BIOMED RESEARCH INTERNATIONAL, 2015, 2015
  • [8] Dysregulation of microRNA-34a expression causes drug-resistance to 5-FU in human colon cancer DLD-1 cells
    Akao, Yukihiro
    Noguchi, Shunsuke
    Iio, Akio
    Kojima, Keitaro
    Takagi, Takeshi
    Naoe, Tomoki
    [J]. CANCER LETTERS, 2011, 300 (02) : 197 - 204
  • [9] miRNAs driving diagnosis, prognosis and progression in Merkel cell carcinoma
    AL-Noshokaty, Tohada M.
    Elballal, Mohammed S.
    Helal, Gouda Kamel
    Abulsoud, Ahmed I.
    Elshaer, Shereen Saeid
    El-Husseiny, Ahmed A.
    Fathi, Doaa
    Abdelmaksoud, Nourhan M.
    Mageed, Sherif S. Abdel
    Midan, Heba M.
    Zaki, Mohamed Bakr
    Abd-Elmawla, Mai A.
    Rizk, Nehal I.
    Elrebehy, Mahmoud A.
    Zewail, Moataz B.
    Mohammed, Osama A.
    Doghish, Ahmed S.
    [J]. PATHOLOGY RESEARCH AND PRACTICE, 2023, 249
  • [10] Role of long non-coding RNAs in pancreatic cancer pathogenesis and treatment resistance- A review
    Al-Noshokaty, Tohada M.
    Mansour, Abdallah
    Abdelhamid, Rehab
    Abdellatif, Nourhan
    Alaaeldien, Ayat
    Reda, Tasnim
    Abdelmaksoud, Nourhan M.
    Doghish, Ahmed S.
    Abulsoud, Ahmed I.
    Elshaer, Shereen Saeid
    [J]. PATHOLOGY RESEARCH AND PRACTICE, 2023, 245
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