Biomaterial scaffolds in maxillofacial bone tissue engineering: A review of recent advances

被引：84
作者：
Huang, Xiangya [1 ,2 ]
Lou, Yaxin [1 ,2 ]
Duan, Yihong [1 ,2 ]
Liu, He [3 ]
Tian, Jun [1 ,2 ]
Shen, Ya [3 ,4 ]
Wei, Xi [1 ,2 ,5 ]
机构：
[1] Sun Yat Sen Univ, Hosp Stomatol, Guanghua Sch Stomatol, Guangzhou, Peoples R China
[2] Guangdong Prov Key Lab Stomatol, Guangzhou, Peoples R China
[3] Univ British Columbia, Div Endodont, Dept Oral Biol & Med Sci, Vancouver, BC, Canada
[4] Univ British Columbia, Fac Dent, Dept Oral Biol & Med Sci, Div Endodont, Vancouver, BC V6T 1Z3, Canada
[5] Sun Yat Sen Univ, Hosp Stomatol, Guanghua Sch Stomatol, 56 Ling Yuan Xi Rd, Guangzhou 510055, Peoples R China
来源：
BIOACTIVE MATERIALS | 2024年 / 33卷
基金：
中国国家自然科学基金;
关键词：
Biomaterial scaffolds; Maxillofacial region; Bone regeneration; Tissue engineering; PLATELET-RICH FIBRIN; MESENCHYMAL STEM-CELLS; MECHANICAL-PROPERTIES; BLOCK GRAFTS; REGENERATION; ANTIBACTERIAL; HYDROGEL; DEFECTS; REPAIR; MINERALIZATION;
D O I：
10.1016/j.bioactmat.2023.10.031
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Maxillofacial bone defects caused by congenital malformations, trauma, tumors, and inflammation can severely affect functions and aesthetics of maxillofacial region. Despite certain successful clinical applications of biomaterial scaffolds, ideal bone regeneration remains a challenge in maxillofacial region due to its irregular shape, complex structure, and unique biological functions. Scaffolds that address multiple needs of maxillofacial bone regeneration are under development to optimize bone regeneration capacity, costs, operational convenience. etc. In this review, we first highlight the special considerations of bone regeneration in maxillofacial region and provide an overview of the biomaterial scaffolds for maxillofacial bone regeneration under clinical examination and their efficacy, which provide basis and directions for future scaffold design. Latest advances of these scaffolds are then discussed, as well as future perspectives and challenges. Deepening our understanding of these scaffolds will help foster better innovations to improve the outcome of maxillofacial bone tissue engineering.
引用
收藏
页码：129 / 156
页数：28
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