Restless legs syndrome, neuroleptic-induced akathisia, and opioid-withdrawal restlessness: shared neuronal mechanisms?

被引：3
作者：
Ferre, Sergi [1 ,8 ]
Winkelman, John [2 ,3 ]
Garcia-Borreguero, Diego [4 ]
Belcher, Annabelle [5 ]
Chang, Joy [6 ]
Earley, Christopher [7 ]
机构：
[1] Natl Inst Drug Abuse, Integrat Neurobiol Sect, Intramural Res Program, NIH, Baltimore, MD USA
[2] Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Boston, MA USA
[3] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Boston, MA USA
[4] Sleep Res Inst, Madrid, Spain
[5] Univ Maryland, Sch Med, Dept Psychiat, Div Addict Res & Treatment, Baltimore, MD USA
[6] Univ Maryland, Sch Med, Dept Psychiat, Subst Abuse Consultat Serv, Baltimore, MD USA
[7] Johns Hopkins Univ, Sch Med, Dept Neurol & Sleep Med, Baltimore, MD USA
[8] Natl Inst Drug Abuse, IRP, NIH, Triad Technol Bldg,333 Cassell Dr, Baltimore, MD 21224 USA
来源：
SLEEP | 2024年 / 47卷 / 03期
关键词：
restless legs syndrome; akathisia; neuroleptics; opioid withdrawal; ENDOGENOUS OPIATE SYSTEM; EKBOM DISEASE; DOPAMINE; DETOXIFICATION; DEPRESSION; MANAGEMENT; DEPENDENCE; RECEPTORS; STRIATUM; PUTAMEN;
D O I：
10.1093/sleep/zsad273
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Restlessness is a core symptom underlying restless legs syndrome (RLS), neuroleptic-induced akathisia, and opioid withdrawal. These three conditions also share other clinical components suggesting some overlap in their pathophysiology. Recent prospective studies demonstrate the frequent incidence of RLS-like symptoms during opioid withdrawal and supervised prescription opioid tapering. Based on the therapeutic role of mu-opioid receptor (MOR) agonists in the three clinical conditions and recent preclinical experimental data in rodents, we provide a coherent and unifying neurobiological basis for the restlessness observed in these three clinical syndromes and propose a heuristic hypothesis of a key role of the specific striatal neurons that express MORs in akathisia/restlessness. Graphical Abstract
引用
收藏
页数：6
相关论文
共 55 条
  • [1] AKPINAR S, 1987, CLIN NEUROPHARMACOL, V10, P69
  • [2] Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report
    Allen, Richard P.
    Picchietti, Daniel L.
    Auerbach, Michael
    Cho, Yong Won
    Connor, James R.
    Earley, Christopher J.
    Garcia-Borreguero, Diego
    Kotagal, Suresh
    Manconi, Mauro
    Ondo, William
    Ulfberg, Jan
    Winkelman, John W.
    [J]. SLEEP MEDICINE, 2018, 41 : 27 - 44
  • [3] Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria - history, rationale, description, and significance
    Allen, Richard P.
    Picchietti, Daniel L.
    Garcia-Borreguero, Diego
    Ondo, William G.
    Walters, Arthur S.
    Winkelman, John W.
    Zucconi, Marco
    Ferri, Raffaele
    Trenkwalder, Claudia
    Lee, Hochang B.
    [J]. SLEEP MEDICINE, 2014, 15 (08) : 860 - 873
  • [4] Abnormally increased CSF 3-Ortho-methyldopa (3-OMD) in untreated restless legs syndrome (RLS) patients indicates more severe disease and possibly abnormally increased dopamine synthesis
    Allen, Richard P.
    Connor, James R.
    Hyland, Keith
    Earley, Christopher J.
    [J]. SLEEP MEDICINE, 2009, 10 (01) : 123 - 128
  • [5] Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors
    Bello, Estefania P.
    Mateo, Yolanda
    Gelman, Diego M.
    Noain, Daniela
    Shin, Jung H.
    Low, Malcolm J.
    Alvarez, Veronica A.
    Lovinger, David M.
    Rubinstein, Marcelo
    [J]. NATURE NEUROSCIENCE, 2011, 14 (08) : 1033 - U128
  • [6] BLOM S, 1961, ACTA MED SCAND, V170, P689
  • [7] The Striosome and Matrix Compartments of the Striatum: A Path through the Labyrinth from Neurochemistry toward Function
    Brimblecombe, Katherine R.
    Cragg, Stephanie J.
    [J]. ACS CHEMICAL NEUROSCIENCE, 2017, 8 (02): : 235 - 242
  • [8] Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome
    Connor, James R.
    Wang, Xin-Sheng
    Allen, Richard P.
    Beard, John L.
    Wiesinger, Jason A.
    Felt, Barbara T.
    Earley, Christopher J.
    [J]. BRAIN, 2009, 132 : 2403 - 2412
  • [9] AUTORADIOGRAPHIC LOCALIZATION OF MU-OPIOID AND NEUROTENSIN RECEPTORS WITHIN THE MESOLIMBIC DOPAMINE SYSTEM
    DILTS, RP
    KALIVAS, PW
    [J]. BRAIN RESEARCH, 1989, 488 (1-2) : 311 - 327
  • [10] Brain-iron deficiency models of restless legs syndrome
    Earley, Christopher J.
    Jones, Byron C.
    Ferre, Sergi
    [J]. EXPERIMENTAL NEUROLOGY, 2022, 356
123456