Memory-related processing is the primary driver of human hippocampal theta oscillations

被引:6
|
作者
Seger, Sarah E. [1 ]
Kriegel, Jennifer L. S. [2 ]
Lega, Brad C. [2 ]
Ekstrom, Arne D. [1 ,3 ,4 ]
机构
[1] Univ Arizona, Neurosci Interdisciplinary Program, 1503 E Univ Blvd, Tucson, AZ 85719 USA
[2] Univ Texas Southwestern Med Sch, Dept Neurosurg, Dallas, TX USA
[3] Univ Arizona, Psychol Dept, 1503 E Univ Blvd, Tucson, AZ 85719 USA
[4] Univ Arizona, Evelyn McKnight Brain Inst, 1503 E Univ Blvd, Tucson, AZ 85719 USA
关键词
LOCAL-FIELD POTENTIALS; NEURONAL OSCILLATIONS; NAVIGATION; POWER; FREQUENCY; MOVEMENT; SEQUENCES; EXTRACTS; DISTANCE; RHYTHMS;
D O I
10.1016/j.neuron.2023.06.015
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Decades of work in rodents suggest that movement is a powerful driver of hippocampal low-frequency ''theta'' oscillations. Puzzlingly, such movement-related theta increases in primates are less sustained and of lower frequency, leading to questions about their functional relevance. Verbal memory encoding and retrieval lead to robust increases in low-frequency oscillations in humans, and one possibility is that memory might be a stronger driver of hippocampal theta oscillations in humans than navigation. Here, neurosurgical patients navigated routes and then immediately mentally simulated the same routes while undergoing intracranial recordings. We found that mentally simulating the same route that was just navigated elicited oscillations that were of greater power, higher frequency, and longer duration than those involving navigation. Our findings suggest that memory is a more potent driver of human hippocampal theta oscillations than navigation, supporting models of internally generated theta oscillations in the human hippocampus.
引用
收藏
页码:3119 / +
页数:17
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