Electrocatalytic oxidative C-H cycloamination towards tricyclic [1,2,4]triazolo-[3,4-i]purine nucleosides mediated by bromide ions

被引：3

作者：

Yang, Qi-Liang ^{[1
]}

Li, Wan-Wan ^{[1
]}

Zhang, Zhong-Xu ^{[1
]}

Zhang, Han-Meng ^{[1
]}

Li, Xian-Jia ^{[1
]}

Guo, Hai-Ming ^{[1
]}

机构：

[1] Henan Normal Univ, Collaborat Innovat Ctr Henan Prov Green Mfg Fine C, Sch Chem & Chem Engn, Minist Educ,Key Lab Green Chem Media & React,State, Xinxiang 453007, Henan, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2023年 / 10卷 / 21期

基金：

中国国家自然科学基金;

关键词：

XANTHINE-OXIDASE INHIBITOR; ELECTROCHEMICAL SYNTHESIS; GENERAL SYNTHESES; AMINATION; ANNULATION; CHEMISTRY; HALOGEN;

D O I：

10.1039/d3qo01050c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An environmentally benign electrochemical approach is presented to access a diversely functionalized [1,2,4]triazolo[3,4-i]purine heterocyclic framework. A bromide-mediated indirect oxidation strategy was utilized to promote intramolecular C(sp(2))-H cycloamination with high efficiency and under mild metal- and oxidant-free conditions. The method exhibits a broad substrate scope, which is well manifested by nucleoside substrates with one or even three hydroxy groups. A radical mechanism was proposed based on cyclic voltammetry and control experiments.

引用

页码：5369 / 5374

页数：6

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