From Bench to Bedside: What Do We Know about Imidazothiazole Derivatives So Far?

被引:11
作者
Guo, Mu [1 ,2 ]
Yu, Xiangbin [1 ,2 ]
Zhu, Yi Zhun [3 ]
Yu, Yue [1 ,2 ]
机构
[1] Fujian Med Univ, Sch Pharm, Fuzhou 350122, Peoples R China
[2] Fujian Ctr New Drug Safety Evaluat, Fuzhou 350122, Peoples R China
[3] Macau Univ Sci & Technol, Sch Pharm, Macau 999078, Peoples R China
关键词
condensed heterocyclic compounds; imidazothiazoles; pharmacological effect; druggable candidates; levamisole; BIOLOGICAL EVALUATION; CALCIUM-CHANNEL; CELL-DEATH; LEVAMISOLE; INHIBITORS; DESIGN; PHARMACOKINETICS; IDENTIFICATION; INFLAMMATION; ANTICANCER;
D O I
10.3390/molecules28135052
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Imidazothiazole derivatives are becoming increasingly important in therapeutic use due to their outstanding physiological activities. Recently, applying imidazothiazole as the core, researchers have synthesized a series of derivatives with biological effects such as antitumor, anti-infection, anti-inflammatory and antioxidant effects. In this review, we summarize the main pharmacological effects and pharmacological mechanisms of imidazothiazole derivates; the contents summarized herein are intended to advance the research and rational development of imidazothiazole-based drugs in the future.
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页数:21
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