A new 124Xe irradiation system for 123I production

被引：4

作者：

da Costa, Osvaldo L. ^{[1
]}

Barcellos, Henrique ^{[1
]}

Matsuda, Hylton ^{[1
]}

Sumiya, Luiz C. do A. ^{[1
]}

Junqueira, Fernando de C. ^{[1
]}

Matsuda, Margareth M. N. ^{[1
]}

Lapolli, Andre L. ^{[1
]}

机构：

[1] CNEN, Inst Pesquisas Energet & Nucl IPEN, Av Prof Lineu Prestes 2242, BR-05508000 Sao Paulo, SP, Brazil

来源：

APPLIED RADIATION AND ISOTOPES | 2023年 / 200卷

关键词：

Cyclotron; Iodine-123; production; Targetry; Proton beam; Radioisotope production; INDUCED NUCLEAR-REACTIONS; HIGH-PURITY I-123; EXCITATION-FUNCTIONS; XENON-124; XE-124;

D O I：

10.1016/j.apradiso.2023.110926

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Since 2001, Nuclear and Energy Research Institute IPEN-CNEN has produced weekly ultrapure iodine-123, using a manual irradiation system, fully developed in IPEN. Iodine-123 radiopharmaceuticals have been produced and distributed to hospitals and clinics of nuclear medicine, where several diagnostic imaging procedures for thyroid, brain and cardiovascular functions are performed. Due to the short half-life and emission of low-energy photons, this radioisotope becomes suitable for diagnosis in children. In the present work, the technical and constructive aspects of a new fully automated irradiation system, dedicated to 123I routine production, employing enriched xenon-124 gas as the target material is presented. This new system consists of a target, a water and helium cooling system, a cryogenic system, an electric power system, and a control and process monitoring unit, composed of supervisory software, connected to a programmable logic controller via personal computer. In this new concept, there is no need for human intervention during radioisotope production, reducing the possibility of eventual failures or incidents involving radioactive material. By using this new system, a specific yield of 2.70 mCi/& mu;Ah per irradiation was achieved in validation runs, and after three years of routine production of iodine 123, the system showed reliability and resilience.

引用

页数：7

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