Research Progress on the Pathogenesis of Aortic Dissection

Aortic dissection is a critical cardiovascular disease due to the separation of media and adventitia caused by the rupture of vascular wall intima. The dis-ease has a high mortality rate of about 1%-3% for each additional hour, since the adventitia of the aorta can rupture and bleed to death at any time. Although great progress has been made in clinical treatment of aortic dissection, and the mortality rate has been sig-nificantly reduced, the pathogenesis is still not very clear. At present, related studies have confirmed that inflammation of aortic wall promotes the occurrence and development of Aortic dissection. Although the mechanism of aortic dissection is more complicated, some studies have shown that the infiltration of mono-cytes/macrophages into the aortic wall is the main pathogenic mechanism of the disease. This review introduces the latest research results on the mecha-nism of macrophage infiltration and plasticity in aortic dissection. (Curr Probl Cardiol 2023;48:101249.)