Palmitate paves the way to lung metastasis

被引：4

作者：

Winkelkotte, Alina M. ^{[1
]}

Schulze, Almut ^{[1
]}

机构：

[1] German Canc Res Ctr, Div Tumor Metab & Microenvironm, Neuenheimer Feld 581, D-69120 Heidelberg, Germany

来源：

TRENDS IN CANCER | 2023年 / 9卷 / 05期

关键词：

NF-kappa B; breast cancer; lung metastasis; palmitate; premetastatic niche; protein acetylation;

D O I：

10.1016/j.trecan.2023.03.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

New findings by Altea-Manzano et al. demonstrate that primary breast tumours or a high-fat diet induce palmitate secretion by alveolar type 2 (AT2) cells to prepare a premetastatic niche that promotes lung metastasis. Palmitate is utilised by cancer cells via carnitine palmitoyltransferase 1a (CPT1a) and lysine acetyltransferase 2a (KAT2a) to acetylate nuclear factor-kappa B (NF-kappa B)/p65. Blocking these enzymes reduced metastasis formation in both lean and high-fat diet mice.

引用

页码：376 / 378

页数：3

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