Palmitate paves the way to lung metastasis

被引:2
作者
Winkelkotte, Alina M. [1 ]
Schulze, Almut [1 ]
机构
[1] German Canc Res Ctr, Div Tumor Metab & Microenvironm, Neuenheimer Feld 581, D-69120 Heidelberg, Germany
关键词
NF-kappa B; breast cancer; lung metastasis; palmitate; premetastatic niche; protein acetylation;
D O I
10.1016/j.trecan.2023.03.001
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
New findings by Altea-Manzano et al. demonstrate that primary breast tumours or a high-fat diet induce palmitate secretion by alveolar type 2 (AT2) cells to prepare a premetastatic niche that promotes lung metastasis. Palmitate is utilised by cancer cells via carnitine palmitoyltransferase 1a (CPT1a) and lysine acetyltransferase 2a (KAT2a) to acetylate nuclear factor-kappa B (NF-kappa B)/p65. Blocking these enzymes reduced metastasis formation in both lean and high-fat diet mice.
引用
收藏
页码:376 / 378
页数:3
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