New insights into follicular regulatory T cells in the intestinal and tumor microenvironments

被引：2

作者：

Cao, Yejin ^{[1
]}

Hou, Yueru ^{[1
]}

Zhao, Longhao ^{[1
]}

Huang, Yijin ^{[1
]}

Liu, Guangwei ^{[1
]}

机构：

[1] Beijing Normal Univ, Coll Life Sci, Key Lab Cell Proliferat & Regulat Biol, Minist Educ, Beijing 100875, Peoples R China

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2023年 / 238卷 / 07期

关键词：

antitumor immunity; GC reaction; intestinal immunity; T cell differentiation; T cell function; Tfr cells; TERTIARY LYMPHOID STRUCTURES; GERMINAL CENTER REACTION; SUPPRESSIVE FUNCTION; HELPER-CELLS; LUNG-CANCER; TFR CELLS; FOXP3; EXPRESSION; RESPONSES; SURVIVAL;

D O I：

10.1002/jcp.31039

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Follicular regulatory T (Tfr) cells are a novel and unique subset of effector regulatory T (Treg) cells that are located in germinal centers (GCs). Tfr cells express transcription profiles that are characteristic of both follicular helper T (Tfh) cells and Treg cells and negatively regulate GC reactions, including Tfh cell activation and cytokine production, class switch recombination and B cell activation. Evidence also shows that Tfr cells have specific characteristics in different local immune microenvironments. This review focuses on the regulation of Tfr cell differentiation and function in unique local immune microenvironments, including the intestine and tumor.

引用

页码：1465 / 1477

页数：13

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