Skeletal muscle dysfunctions in pulmonary arterial hypertension: Effects of aerobic exercise training

被引：5

作者：

Drummond, Filipe Rios ^{[1
]}

Leite, Luciano Bernardes ^{[2
]}

de Miranda, Denise Coutinho ^{[3
,4
]}

Drummond, Lucas Rios ^{[5
]}

Lavorato, Victor Neiva ^{[4
]}

Soares, Leoncio Lopes ^{[2
]}

Neves, Clovis Andrade ^{[1
]}

Natali, Antonio Jose ^{[2
]}

机构：

[1] Univ Fed Vicosa, Dept Gen Biol, Lab Struct Biol, Vicosa, MG, Brazil

[2] Univ Fed Vicosa, Dept Phys Educ, Lab Exercise Biol, Vicosa, MG, Brazil

[3] Univ Fed Ouro Preto, Dept Biol Sci, Lab Cell Signaling, Vicosa, MG, Brazil

[4] Governador Ozanam Coelho Univ Ctr UNIFAGOC, Dept Phys Educ, Uba, Brazil

[5] Univ Fed Minas Gerais, Dept Physiol & Biophys, Lab Endocrinol & Metab, Belo Horizonte, MG, Brazil

来源：

FRONTIERS IN PHYSIOLOGY | 2023年 / 14卷

关键词：

myopathy; pulmonary hypertension; effort; physical performance; aerobic exercise; NECROSIS-FACTOR-ALPHA; RIGHT-VENTRICULAR HYPERTROPHY; INSULIN-RESISTANCE; P38; MAPK; MECHANISMS; INTERLEUKIN-6; INFLAMMATION; ATROPHY; RATS;

D O I：

10.3389/fphys.2023.1148146

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Pulmonary arterial hypertension is associated with skeletal muscle myopathy and atrophy and impaired exercise tolerance. Aerobic exercise training has been recommended as a non-pharmacological therapy for deleterious effects imposed by pulmonary arterial hypertension. Aerobic physical training induces skeletal muscle adaptations via reduced inflammation, improved anabolic processes, decreased hypoxia and regulation of mitochondrial function. These benefits improve physical exertion tolerance and quality of life in patients with pulmonary arterial hypertension. However, the mechanisms underlying the therapeutic potential of aerobic exercise to skeletal muscle disfunctions in patients with pulmonary arterial hypertension are not well understood yet. This minireview highlights the pathways involved in skeletal muscle adaptations to aerobic exercise training in patients with pulmonary arterial hypertension.

引用

页数：6

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