The role of class IIa histone deacetylases in regulating endothelial function

被引:16
作者
Shen, Zexu [1 ]
Bei, Yun [1 ]
Lin, Haoran [1 ]
Wei, Taofeng [1 ]
Dai, Yunjian [1 ]
Hu, Yangmin [1 ]
Zhang, Chao [2 ]
Dai, Haibin [1 ]
机构
[1] Zhejiang Univ, Affiliated Hosp 2, Dept Pharm, Sch Med, Hangzhou, Peoples R China
[2] First Peoples Hosp Hangzhou Linan Dist, Dept Pharm, Hangzhou, Peoples R China
基金
中国国家自然科学基金;
关键词
histone deacetylases; endothelial cells; angiogenesis; atherosclerosis; inflammation; inhibitor; NF-KAPPA-B; MESENCHYMAL TRANSITION; CELL MIGRATION; MICRORNA-17-92; CLUSTER; GENE-EXPRESSION; HDAC INHIBITORS; NUCLEAR EXPORT; NITRIC-OXIDE; FILAMIN B; ANGIOGENESIS;
D O I
10.3389/fphys.2023.1091794
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Vascular endothelial cells (ECs) are monolayer cells located in the inner layer of the blood vessel. Endothelial function is crucial in maintaining local and systemic homeostasis and is precisely regulated by sophisticated signaling pathways and epigenetic regulation. Endothelial dysfunctions are the main factors for the pathophysiological process of cardiovascular and cerebrovascular diseases like atherosclerosis, hypertension, and stroke. In these pathologic processes, histone deacetylases (HDACs) involve in epigenetic regulation by removing acetyl groups from lysine residues of histones and regulating downstream gene expression. Among all HDACs, Class IIa HDACs (HDAC4, 5, 7, 9) contain only an N-terminal regulatory domain, exert limited HDAC activity, and present tissue-specific gene regulation. Here, we discuss and summarize the current understanding of this distinct subfamily of HDACs in endothelial cell functions (such as angiogenesis and immune response) with their molecular underpinnings. Furthermore, we also present new thoughts for further investigation of HDAC inhibitors as a potential treatment in several vascular diseases.
引用
收藏
页数:12
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