Blood concentrations of neopterin and biopterin in subjects with depression: A systematic review and meta-analysis

被引：23

作者：

Cavaleri, Daniele ^{[1
]}

Bartoli, Francesco ^{[1
]}

Capogrosso, Chiara A. ^{[1
]}

Guzzi, Pierluca ^{[1
]}

Moretti, Federico ^{[1
]}

Riboldi, Ilaria ^{[1
]}

Misiak, Blazej ^{[2
]}

Kishi, Taro ^{[3
]}

Rubin, Robert T. ^{[4
,5
]}

Fuchs, Dietmar ^{[6
]}

Crocamo, Cristina ^{[1
]}

Carra, Giuseppe ^{[1
,7
]}

机构：

[1] Univ Milano Bicocca, Dept Med & Surg, Via Cadore 48, I-20900 Monza, Italy

[2] Wroclaw Med Univ, Dept Psychiat, Div Consultat Psychiat & Neurosci, Pasteura 10 St, PL-50367 Wroclaw, Poland

[3] Fujita Hlth Univ, Dept Psychiat, Sch Med, Toyoake, Aichi 4701192, Japan

[4] UCLA, Dept Psychiat & Biobehav Sci, David Geffen Sch Med, Los Angeles, CA 90095 USA

[5] Ventura Cty Med Ctr, Community Mem Hlth Syst, 147 Brent St, Ventura, CA 93003 USA

[6] Med Univ Innsbruck, Inst Biol Chem, Bioctr, Innrain 80-82, A-6020 Innsbruck, Austria

[7] UCL, Div Psychiat, Maple House 149, London W1T 7BN, England

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2023年 / 120卷

关键词：

Neopterin; Biopterin; Depression; Systematic review; Meta-analysis; MAJOR DEPRESSION; TRYPTOPHAN-METABOLISM; NITRIC-OXIDE; SERUM-LEVELS; AMINO-ACIDS; INFLAMMATION; TETRAHYDROBIOPTERIN; ASSOCIATION; SCHIZOPHRENIA; DISORDER;

D O I：

10.1016/j.pnpbp.2022.110633

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Pteridines, such as neopterin, biopterin, and tetrahydrobiopterin (BH4), may be involved in depression pathophysiology owing to their links to immune-inflammatory response, oxidative and nitrosative stress, and monoaminergic transmission. Nonetheless, studies assessing pteridines in depression are inconsistent. We conducted a systematic review and meta-analysis of observational studies comparing blood pteridine con-centrations between subjects with depression and healthy controls (HCs).Methods: We searched Embase, MEDLINE, and PsycInfo for articles indexed through November 2021. Study quality was appraised, evaluating age and gender comparability between groups, sample representativeness, and methods to assess depression. Random-effects meta-analyses were carried out, generating pooled standardized mean differences (SMDs). Heterogeneity across studies was estimated using the I2 statistic.Results: Twenty-four studies, involving 3075 subjects, were included. Individuals with depression showed blood neopterin concentrations higher than HCs (k = 19; SMD = 0.36; p < 0.001) with moderate heterogeneity across studies (I2 = 58.2%). No moderating role of age, gender, or type of blood sample was found. Sensitivity analyses showed no impact of inconsistency and quality of studies on findings. Neopterin concentrations were higher among individuals with major depressive disorder compared to HCs (SMD = 0.44; p < 0.001). This held true also when considering only drug-free subjects (SMD = 0.68; p = 0.003). No differences in biopterin concentrations were found between subjects with depression and HCs (k = 5; SMD = -0.35; p = 0.086), though this result was limited by inconsistency of findings (I2 = 77.9%) and quality of studies. Finally, no sufficient data were available for a meta-analysis on BH4. Conclusions: As a whole, our work partly supports the hypothesis of an imbalance of pteridine metabolism in depression.

引用

页数：11

共 74 条

[21] Nitric oxide and neopterin in bipolar affective disorder [J].