Association of diet quality with glycemia, insulinemia, and insulin resistance in families at high risk for type 2 diabetes mellitus in Europe: Feel4 Diabetes Study

被引：1

作者：

Botsi, E. ^{[1
]}

Karatzi, K. ^{[2
]}

Mavrogianni, C. ^{[1
]}

Tsochev, Kaloyan ^{[3
]}

Gonzalez-Gil, Esther M. ^{[4
,5
,6
]}

Rado, S. ^{[7
]}

Kivela, J. ^{[8
]}

Wikstrom, K. ^{[8
]}

Cardon, G. ^{[9
]}

Rurik, I ^{[10
]}

Liatis, S. ^{[11
]}

Tankova, Tsvetalina ^{[12
]}

Iotova, Violeta ^{[3
]}

Moreno, Luis A. ^{[6
]}

Makrillakis, K. ^{[11
]}

Manios, Y. ^{[1
,13
]}

Tsigos, C. ^{[1
]}

机构：

[1] Harokopio Univ, Dept Nutr & Dietet, Sch Hlth Sci & Educ, Athens, Greece

[2] Agr Univ Athens, Dept Food Sci & Human Nutr, Athens, Greece

[3] Med Univ Varna, Dept Pediat, Varna, Bulgaria

[4] Univ Granada, Dept Biochem & Mol Biol 2, Inst Nutr & Tecnol Alimentos, Ctr Biomed Res CIBM, Granada, Spain

[5] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid, Spain

[6] Univ Zaragoza, Sch Hlth Sci EUCS, Growth Exercise Nutr & Dev Res Grp, Zaragoza, Spain

[7] Univ Debrecen, Fac Hlth, Doctoral Sch Hlth Sci, Debrecen, Hungary

[8] Finnish Inst Hlth & Welf, Dept Publ Hlth Solut, Helsinki, Finland

[9] Univ Ghent, Fac Med & Hlth Sci, Dept Movement & Sports Sci, Ghent, Belgium

[10] Univ Debrecen, Fac Med, Dept Family & Occupat Med, Debrecen, Hungary

[11] Natl & Kapodistrian Univ Athens, Med Sch, Athens, Greece

[12] Med Univ Sofia, Clin Ctr Endocrinol, Sofia, Bulgaria

[13] Hellen Mediterranean Univ Res Ctr, Inst Agrifood & Life Sci, Agrohlth, Iraklion, Greece

来源：

NUTRITION | 2023年 / 105卷

关键词：

Diet quality; Prediabetes; Type 2 diabetes mellitus; Insulin resistance; Socioeconomic status; Blood glucose management; Healthy Diet Score; Insulin management; SCORE; METAANALYSIS; HOMEOSTASIS; GLUCOSE;

D O I：

10.1016/j.nut.2022.111805

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Objective: The aim of the present study was to investigate the association of diet quality with fasting glycemia, insulinemia, and insulin resistance in a cross-sectional sample of adults from families at high risk for type 2 diabetes mellitus (T2DM) from six European countries, taking into account their socioeconomic status (SES). Methods: Baseline data from non-diabetic adults from the Feel4 Diabetes study were used and diet was assessed by the Healthy Diet Score (HDS). Insulin resistance (IR) was determined by homeostasis model assessment of IR (HOMA-IR). Sociodemographic and lifestyle characteristics were assessed through standardized questionnaires. Multiple linear regressions were adjusted for many confounders, in the total sample and by SES category. Results: In 1980 adults, the third tertile of diet quality was inversely associated with insulin levels ( -1.48; 95% confidence interval [CI], -2.34 to 0.62), and HOMA-IR ( -0.33; 95% CI, -0.57 to 0.09), yet with no statistically significant results for glucose levels. In the SES subgroup analysis, in the high SES group, both second and third diet score tertiles were inversely associated with insulin levels ( -1.81; 95% CI, -2.66 to 0.95) and HOMA-IR values ( -0.45; 95% CI -0.69 to 0.21), independent of age, sex, smoking and body mass index. No such associations were observed for glucose levels in the high SES group and for all indices in the low SES group. Conclusion: In adults from families at high risk for T2DM, higher diet quality was negatively associated with fasting insulin levels and IR, only in the high SES group and not in the low SES group. Future larger studies may be able to explore further this association, as well as the potential factors that mitigate its strength in the low SES groups. (C) 2022 Elsevier Inc. All rights reserved.

引用

页数：6

共 32 条

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