Mental health, pain and likelihood of opioid misuse among adults with sickle cell disease

被引：2

作者：

Jonassaint, Charles R. ^{[1
,15
]}

Parchuri, Ektha ^{[1
]}

O'Brien, Julia A. ^{[1
]}

Lalama, Christina M. ^{[1
]}

Lin, Jonathan ^{[1
]}

Badawy, Sherif M. ^{[2
,3
]}

Hamm, Megan E. ^{[1
]}

Stinson, Jennifer ^{[4
]}

Lalloo, Chitra ^{[5
,6
]}

Carroll, C. Patrick ^{[7
]}

Saraf, Santosh L. ^{[8
]}

Gordeuk, Victor R. ^{[8
]}

Cronin, Robert ^{[9
]}

Shah, Nirmish ^{[10
]}

Lanzkron, Sophie M. ^{[7
]}

Liles, Darla ^{[11
]}

Trimnell, Cassandra ^{[12
]}

Bailey, Lakiea ^{[13
]}

Lawrence, Raymona H. ^{[14
]}

Abebe, Kaleab Z. ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Med, Pittsburgh, PA USA

[2] Northwestern Univ, Feinberg Sch Med, Dept Pediat, Chicago, IL USA

[3] Ann & Robert H Lurie Childrens Hosp Chicago, Div Hematol Oncol & Stem Cell Transplant, Chicago, IL USA

[4] Univ Toronto, Hosp Sick Children & Lawrence S Bloomberg, Child Hlth Evaluat Sci Res Inst, Fac Nursing, Toronto, ON, Canada

[5] Hosp Sick Children, Child Hlth Evaluat Sci, Toronto, ON, Canada

[6] Univ Toronto, Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada

[7] Johns Hopkins Sch Med, Johns Hopkins Sickle Cell Ctr Adults, Dept Psychiat & Behav Sci, Baltimore, MD USA

[8] Univ Illinois, Sickle Cell Ctr, Dept Med, Chicago, IL USA

[9] Ohio State Univ, Dept Internal Med, Columbus, OH USA

[10] Duke Univ, Sickle Cell Transit Program, Div Hematol, Div Pediat Hematol Oncol, Durham, NC USA

[11] East Carolina Univ, Dept Internal Med, Greenville, NC USA

[12] Sickle Cell 101, San Jose, CA USA

[13] Sickle Cell Community Consortium, Atlanta, GA USA

[14] Georgia Southern Univ Statesboro, Jiann Ping Hsu Coll Publ Hlth, Statesboro, GA USA

[15] 230 McKee Pl, Suite 600, Pittsburgh, PA 15213 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2024年 / 204卷 / 03期

关键词：

depressive symptoms; ecological momentary assessment; eHealth; mental health; depression; mHealth; pain; quality of life; sickle cell disease; QUALITY-OF-LIFE; GENERALIZED ANXIETY DISORDER; RESOURCE UTILIZATION; MAJOR DEPRESSION; ASSOCIATION; CHILDREN; SEVERITY; SYMPTOMS; CARE; PREVALENCE;

D O I：

10.1111/bjh.19243

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Depressive symptoms are prevalent in individuals living with sickle cell disease (SCD) and may exacerbate pain. This study examines whether higher depressive symptoms are associated with pain outcomes, pain catastrophizing, interference and potential opioid misuse in a large cohort of adults with SCD. The study utilized baseline data from the 'CaRISMA' trial, which involved 357 SCD adults with chronic pain. Baseline assessments included pain intensity, daily mood, the Patient Health Questionnaire (PHQ), the Generalized Anxiety Disorders scale, PROMIS Pain Interference, Pain Catastrophizing Scale, the Adult Sickle Cell Quality of Life Measurement Information System and the Current Opioid Misuse Measure. Participants were categorized into 'high' or 'low' depression groups based on PHQ scores. Higher depressive symptoms were significantly associated with increased daily pain intensity, negative daily mood, higher pain interference and catastrophizing, poorer quality of life and a higher likelihood of opioid misuse (all p < 0.01). SCD patients with more severe depressive symptoms experienced poorer pain outcomes, lower quality of life and increased risk of opioid misuse. Longitudinal data from this trial will determine whether addressing depressive symptoms may potentially reduce pain frequency and severity in SCD.

引用

页码：1029 / 1038

页数：10

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