Rehabilitation Modulates High-Order Interactions Among Large-Scale Brain Networks in Subacute Stroke

被引：8

作者：

Pirovano, I. ^{[1
]}

Antonacci, Y. ^{[2
]}

Mastropietro, A. ^{[1
]}

Bara, C. ^{[2
]}

Sparacino, L. ^{[2
]}

Guanziroli, E. ^{[3
]}

Molteni, F. ^{[3
]}

Tettamanti, M. ^{[4
]}

Faes, L. ^{[2
]}

Rizzo, G. ^{[1
]}

机构：

[1] CNR, Inst Biomed Technol, I-20054 Milan, Italy

[2] Univ Palermo, Dept Engn, I-90128 Palermo, Italy

[3] Osped Valduce, Villa Beretta Rehabil Ctr, I-23845 Lecce, Italy

[4] Univ Milano Bicocca, Dept Psychol, I-20126 Milan, Italy

来源：

IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING | 2023年 / 31卷

关键词：

EEG; functional connectivity; granger causality; high-order interactions; redundancy; rehabilita-tion; resting-state networks; synergy; stroke; RESTING-STATE NETWORKS; LINEAR-DEPENDENCE; CONNECTIVITY; REORGANIZATION; DYNAMICS; FEEDBACK;

D O I：

10.1109/TNSRE.2023.3332114

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The recovery of motor functions after stroke is fostered by the functional integration of large-scale brain networks, including the motor network (MN) and high-order cognitive controls networks, such as the default mode (DMN) and executive control (ECN) networks. In this paper, electroencephalography signals are used to investigate interactions among these three resting state networks (RSNs) in subacute stroke patients after motor rehabilitation. A novel metric, the O-information rate (OIR), is used to quantify the balance between redundancy and synergy in the complex high-order interactions among RSNs, as well as its causal decomposition to identify the direction of information flow. The paper also employs conditional spectral Granger causality to assess pairwise directed functional connectivity between RSNs. After rehabilitation, a synergy increase among these RSNs is found, especially driven by MN. From the pairwise description, a reduced directed functional connectivity towards MN is enhanced after treatment. Besides, inter-network connectivity changes are associated with motor recovery, for which the mediation role of ECN seems to play a relevant role, both from pairwise and high-order interactions perspective.

引用

页码：4549 / 4560

页数：12

共 73 条

[61] Disruptions of network connectivity predict impairment in multiple behavioral domains after stroke [J].