Oxidative Stress Biomarkers in Cystic Fibrosis and Cystic Fibrosis-Related Diabetes in Children: A Literature Review

被引：5

作者：

Pinzaru, Anca Daniela ^{[1
,2
]}

Mihai, Cristina Maria ^{[1
,2
]}

Chisnoiu, Tatiana ^{[1
,2
]}

Pantazi, Alexandru Cosmin ^{[1
]}

Lupu, Vasile Valeriu ^{[3
]}

Kassim, Mustafa Ali Kassim ^{[4
]}

Lupu, Ancuta ^{[3
]}

Grosan, Elena ^{[2
]}

Al Jumaili, Ahmed Zaki Naji ^{[5
]}

Ion, Irina ^{[1
,2
]}

Stoleriu, Gabriela ^{[6
]}

Ion, Ileana ^{[4
]}

机构：

[1] Ovidius Univ, Fac Med, Dept Pediat, Constanta 900470, Romania

[2] Cty Clin Emergency Hosp Constanta, Dept Pediat, Constanta 900591, Romania

[3] Grigore T Popa Univ Med & Pharm, Dept Pediat, Iasi 700115, Romania

[4] Ovidius Univ, Fac Med, Constanta 900470, Romania

[5] Natl Inst Diabet Nutr & Metab Dis NC Paulescu, Bucharest 020475, Romania

[6] Dunarea de Jos Univ Galati, Fac Med & Pharm, Galati 800008, Romania

来源：

BIOMEDICINES | 2023年 / 11卷 / 10期

关键词：

cystic fibrosis; diabetes mellitus; oxidative stress; children; INSULIN-SECRETION; GLUCOSE-TOLERANCE; BETA-CELLS; CFTR; COMPLICATIONS; MELLITUS; THERAPY; INFLAMMATION; PATHOGENESIS; RESISTANCE;

D O I：

10.3390/biomedicines11102671

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The most common inherited condition that results in death, particularly in those of Caucasian heritage, is cystic fibrosis (CF). Of all the young adults diagnosed with cystic fibrosis, 20% will develop hyperglycemia as a complication, later classified as a disease associated with cystic fibrosis. Impaired insulin secretion and glucose intolerance represent the primary mechanisms associated with diabetes (type 1 or type 2) and cystic fibrosis. Oxidative stress represents the imbalance between oxygen-reactive species and antioxidant defense mechanisms. This pathogenic mechanism is vital in triggering other chronic diseases, including cystic fibrosis-related diabetes. It is essential to understand oxidative stress and the significant impact it has on CFRD. This way, therapies can be individually adjusted and tailored to each patient's needs. This review aims to understand the connection between CFRD and oxidative stress. As a subsidiary element, we analyzed the effects of glycemic balance on complications and their evolution over time, providing insights into their potential benefits in mitigating oxidative stress-associated complications.

引用

页数：18

共 134 条

[31] Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation [J].