Acute and post-acute multidisciplinary outcomes of newborns born from mothers with SARS-CoV-2 infection during pregnancy or the perinatal period

被引：2

作者：

Buonsenso, Danilo ^{[1
,2
,3
,11
]}

Poretti, Giulia ^{[4
]}

Mariani, Francesco ^{[5
]}

Colonna, Arianna Turriziani ^{[5
]}

Costa, Simonetta ^{[6
]}

Giordano, Lucia ^{[6
]}

Priolo, Francesca ^{[6
]}

Conti, Guido ^{[7
]}

Tizio, Angelo ^{[7
]}

Rodolico, Daniela ^{[7
]}

Amorelli, Giulia Maria ^{[8
,9
]}

Orazi, Lorenzo ^{[8
]}

Petrianni, Maria ^{[8
]}

Ricci, Daniela ^{[8
]}

Lanzone, Antonio

Sanguinetti, Maurizio ^{[3
,10
]}

Cattani, Paola ^{[3
,10
]}

Raffaelli, Francesca ^{[10
]}

Sali, Michela ^{[3
,10
]}

Zampino, Giuseppe ^{[6
,10
]}

Vento, Giovanni ^{[6
,10
]}

Valentini, Piero ^{[6
,10
]}

机构：

[1] Fdn Policlin Univ A Gemelli IRCCS, Dept Woman & Child Hlth & Publ Hlth, Rome, Italy

[2] Univ Cattolica Sacro Cuore, Global Hlth Res Inst, Ist Igiene, Rome, Italy

[3] Univ Cattolica Sacro Cuore, Dipartimento Sci Biotecnolog Base, Clin Intensivolog & Perioperatorie Sez Microbiol, Sez Microbiol, Rome, Italy

[4] Univ Cattolica Sacro Cuore, Med & Surg, I-00168 Rome, Italy

[5] Fdn Policlin Univ A Gemelli IRCCS, Dept Woman & Child Hlth & Publ Hlth, Rome, Italy

[6] Univ Cattolica Sacro Cuore, Pediat Resident, I-00168 Rome, Italy

[7] Univ Cattolica Sacro Cuore, Fdn Policlin A Gemelli IRCCS, Rome, Italy

[8] Univ Cattolica Sacro Cuore, Gemelli Fdn IRCSS, Dept Ophthalmol, Rome, Italy

[9] IAPB Italia Onlus Fdn Policlin Agostino Gemelli IR, Natl Ctr Serv & Res Prevent Blindness & Rehabil Lo, Rome, Italy

[10] Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Sci Lab & Infettivolog, Rome, Italy

[11] Largo A Gemelli 8, I-00168 Rome, Italy

来源：

HELIYON | 2023年 / 9卷 / 09期

关键词：

COVID-19; IMPACT;

D O I：

10.1016/j.heliyon.2023.e19206

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Introduction.We performed a single-center, prospective, observational study of newborns born from mothers with microbiologically confirmed SARS-CoV-2 infection in pregnancy or at time of delivery to evaluate acute and mid-term multidisciplinary outcomes.Methods. Infants were offered a multidisciplinary follow-up consisting of nasopharyngeal Polymerase Chain Reaction test at birth and at 48-72 h of life, auxological and ophthalmological assessments, and serologic testing.Results. 791 women and their 791 children (52.3% males) were included. Most placentas (94.9%) had abnormal inflammatory findings. 171 (27.3%) and 36 (13.7%) children respectively had pathological TEOAEs in at least one ear and bilaterally, while only four of the 85 children that underwent ABR had pathological findings (4.7%). 64 children underwent fluorescein angiography, which resulted pathological only in 1 case (1.6%). Anti-SARSCoV-2 IgGs were found in up to 60% of children tested at six months of age. Our findings showed no association between the maternal vaccination status or the presence of maternal symptoms during pregnancy and neonatal outcomes.Conclusions.

引用

页数：11

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